Fanconi anemia group D2 protein
Intramolecular
Cysteine 432 and cysteine 469
Cysteine 310 and cysteine 342
Cysteine 1058 and cysteine 1059
Cysteine 1058 and cysteine 1128
Cysteine 113 and cysteine 117 L
Cysteine 1294 and cysteine 1342
Cysteine 657 and cysteine 740
Cysteine 801 and cysteine 1015
Cysteine 1024 and cysteine 1061
6vae B 432 B 469
A redox-regulated disulphide may form within Fanconi anemia group D2 protein between cysteines 432 and 469.
Details
Redox score ?
85
PDB code
6vae
Structure name
mono-ubiquitinated fanconi anemia id complex bound to icl dna
Structure deposition date
2019-12-17
Thiol separation (Å)
3
Half-sphere exposure sum ?
63
Minimum pKa ?
8
% buried
56
Peptide accession
Q9BXW9
Residue number A
432
Residue number B
469
Peptide name
Fanconi anemia group D2 protein
Ligandability
Cysteine 432 of Fanconi anemia group D2 protein
Cysteine 469 of Fanconi anemia group D2 protein
7ay1 B 310 B 342
A redox-regulated disulphide may form within Fanconi anemia group D2 protein between cysteines 310 and 342. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
7ay1
Structure name
cryo-em structure of usp1-uaf1 bound to mono-ubiquitinated fancd2, and fanci
Structure deposition date
2020-11-10
Thiol separation (Å)
8
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
6
Peptide accession
Q9BXW9
Residue number A
310
Residue number B
342
Peptide name
Fanconi anemia group D2 protein
Ligandability
Cysteine 310 of Fanconi anemia group D2 protein
Cysteine 342 of Fanconi anemia group D2 protein
3s4w B 1058 B 1059
A redox-regulated disulphide may form within Fanconi anemia group D2 protein homolog between cysteines 1058 and 1059. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
3s4w
Structure name
structure of the fanci-fancd2 complex
Structure deposition date
2011-05-20
Thiol separation (Å)
7
Half-sphere exposure sum ?
71
Minimum pKa ?
10
% buried
67
Peptide accession
Q80V62
Residue number A
1058
Residue number B
1059
Peptide name
Fanconi anemia group D2 protein homolog
Ligandability
Cysteine 1058 of Fanconi anemia group D2 protein homolog
Cysteine 1059 of Fanconi anemia group D2 protein homolog
3s4w B 1058 B 1128
A redox-regulated disulphide may form within Fanconi anemia group D2 protein homolog between cysteines 1058 and 1128. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
3s4w
Structure name
structure of the fanci-fancd2 complex
Structure deposition date
2011-05-20
Thiol separation (Å)
8
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
66
Peptide accession
Q80V62
Residue number A
1058
Residue number B
1128
Peptide name
Fanconi anemia group D2 protein homolog
Ligandability
Cysteine 1058 of Fanconi anemia group D2 protein homolog
Cysteine 1128 of Fanconi anemia group D2 protein homolog
6vae B 113 B 117
A redox-regulated disulphide may form within Fanconi anemia group D2 protein between cysteines 113 and 117. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
6vae
Structure name
mono-ubiquitinated fanconi anemia id complex bound to icl dna
Structure deposition date
2019-12-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
72
Minimum pKa ?
11
% buried
86
Peptide accession
Q9BXW9
Residue number A
113
Residue number B
117
Peptide name
Fanconi anemia group D2 protein
Ligandability
Cysteine 113 of Fanconi anemia group D2 protein
Cysteine 117 of Fanconi anemia group D2 protein
6vaa B 1294 B 1342
A redox-regulated disulphide may form within Fanconi anemia group D2 protein between cysteines 1294 and 1342. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
6vaa
Structure name
structure of the fanconi anemia id complex bound to icl dna
Structure deposition date
2019-12-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
76
Minimum pKa ?
10
% buried
80
Peptide accession
Q9BXW9
Residue number A
1294
Residue number B
1342
Peptide name
Fanconi anemia group D2 protein
Ligandability
Cysteine 1294 of Fanconi anemia group D2 protein
Cysteine 1342 of Fanconi anemia group D2 protein
6vae B 657 B 740
A redox-regulated disulphide may form within Fanconi anemia group D2 protein between cysteines 657 and 740. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
6vae
Structure name
mono-ubiquitinated fanconi anemia id complex bound to icl dna
Structure deposition date
2019-12-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
68
Peptide accession
Q9BXW9
Residue number A
657
Residue number B
740
Peptide name
Fanconi anemia group D2 protein
Ligandability
Cysteine 657 of Fanconi anemia group D2 protein
Cysteine 740 of Fanconi anemia group D2 protein
8a9j B 801 B 1015
A redox-regulated disulphide may form within Fanconi anemia group D2 protein between cysteines 801 and 1015. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
8a9j
Structure name
cryo-em structure of usp1-uaf1 bound to fanci and mono-ubiquitinated fancd2 without ml323 (consensus reconstruction)
Structure deposition date
2022-06-28
Thiol separation (Å)
10
Half-sphere exposure sum ?
57
Minimum pKa ?
11
% buried
80
Peptide accession
Q9BXW9
Residue number A
801
Residue number B
1015
Peptide name
Fanconi anemia group D2 protein
Ligandability
Cysteine 801 of Fanconi anemia group D2 protein
Cysteine 1015 of Fanconi anemia group D2 protein
6vaf B 1024 B 1061
A redox-regulated disulphide may form within Fanconi anemia group D2 protein between cysteines 1024 and 1061. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
30
PDB code
6vaf
Structure name
structure of mono-ubiquitinated fancd2 bound to non-ubiquitinated fanci and to dna
Structure deposition date
2019-12-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
12
% buried
98
Peptide accession
Q9BXW9
Residue number A
1024
Residue number B
1061
Peptide name
Fanconi anemia group D2 protein
Ligandability
Cysteine 1024 of Fanconi anemia group D2 protein
Cysteine 1061 of Fanconi anemia group D2 protein
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