a tool for identifying drug-targetable redox-active disulphides

Protein kinase C and casein kinase substrate in neurons protein 1

Intramolecular

Cysteine 164 and cysteine 198

A redox-regulated disulphide may form within Protein kinase C and casein kinase substrate in neurons protein 1 between cysteines 164 and 198. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

47

PDB code

Structure name

crystal structure of human pacsin1 f-bar domain (c2 lattice)

Structure deposition date

2009-05-01

Thiol separation (Å)

9

Half-sphere exposure sum ?

53

Minimum pK_a ?

10

% buried

6

Peptide accession

Residue number A

164

Residue number B

198

Peptide name

Protein kinase C and casein kinase substrate in neurons protein 1

Ligandability

Cysteine 164 of Protein kinase C and casein kinase substrate in neurons protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 198 of Protein kinase C and casein kinase substrate in neurons protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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