ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Inosine triphosphate pyrophosphatase

Intermolecular
Cysteine 146 and cysteine 146
Intramolecular
Cysteine 74 and cysteine 76
Cysteine 74 and cysteine 116
A redox-regulated disulphide may form between two units of Inosine triphosphate pyrophosphatase at cysteines 146 and 146. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
2j4e
Structure name
the itp complex of human inosine triphosphatase
Structure deposition date
2006-08-29
Thiol separation (Å)
7
Half-sphere exposure sum ?
78
Minimum pKa ?
11
% buried
76
Peptide A name
Inosine triphosphate pyrophosphatase
Peptide B name
Inosine triphosphate pyrophosphatase
Peptide A accession
Q9BY32
Peptide B accession
Q9BY32
Peptide A residue number
146
Peptide B residue number
146

Ligandability

A redox-regulated disulphide may form within Inosine triphosphate pyrophosphatase between cysteines 74 and 76.

Details

Redox score ?
61
PDB code
2j4e
Structure name
the itp complex of human inosine triphosphatase
Structure deposition date
2006-08-29
Thiol separation (Å)
5
Half-sphere exposure sum ?
76
Minimum pKa ?
8
% buried
100
Peptide accession
Q9BY32
Residue number A
74
Residue number B
76
Peptide name
Inosine triphosphate pyrophosphatase

Ligandability

Cysteine 74 of Inosine triphosphate pyrophosphatase

Cysteine 76 of Inosine triphosphate pyrophosphatase

A redox-regulated disulphide may form within Inosine triphosphate pyrophosphatase between cysteines 74 and 116. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
2j4e
Structure name
the itp complex of human inosine triphosphatase
Structure deposition date
2006-08-29
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
14
% buried
100
Peptide accession
Q9BY32
Residue number A
74
Residue number B
116
Peptide name
Inosine triphosphate pyrophosphatase

Ligandability

Cysteine 74 of Inosine triphosphate pyrophosphatase

Cysteine 116 of Inosine triphosphate pyrophosphatase

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