SH3 and multiple ankyrin repeat domains protein 3
Intermolecular
Cysteine 41 and cysteine 41
Intramolecular
Cysteine 258 and cysteine 290
Cysteine 290 and cysteine 298
Cysteine 258 and cysteine 298
Cysteine 151 and cysteine 189
Cysteine 232 and cysteine 233
7c7i C 41 D 41
A redox-regulated disulphide may form between two units of SH3 and multiple ankyrin repeat domains protein 3 at cysteines 41 and 41.
Details
Redox score ?
82
PDB code
7c7i
Structure name
crystal structure of shank3 spn domain in complex with gtp-bound rap1b(e30d,k31e)
Structure deposition date
2020-05-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide A name
SH3 and multiple ankyrin repeat domains protein 3
Peptide B name
SH3 and multiple ankyrin repeat domains protein 3
Peptide A accession
Q9BYB0
Peptide B accession
Q9BYB0
Peptide A residue number
41
Peptide B residue number
41
Ligandability
6kyh D 258 D 290
A redox-regulated disulphide may form within SH3 and multiple ankyrin repeat domains protein 3 between cysteines 258 and 290.
Details
Redox score ?
70
PDB code
6kyh
Structure name
crystal structure of shank3 ntd-ank a42k mutant in complex with hras
Structure deposition date
2019-09-18
Thiol separation (Å)
3
Half-sphere exposure sum ?
82
Minimum pKa ?
10
% buried
100
Peptide accession
Q4ACU6
Residue number A
258
Residue number B
290
Peptide name
SH3 and multiple ankyrin repeat domains protein 3
Ligandability
Cysteine 258 of SH3 and multiple ankyrin repeat domains protein 3
Cysteine 290 of SH3 and multiple ankyrin repeat domains protein 3
6kyk A 290 A 298
A redox-regulated disulphide may form within SH3 and multiple ankyrin repeat domains protein 3 between cysteines 290 and 298.
Details
Redox score ?
60
PDB code
6kyk
Structure name
crystal structure of shank3 ntd-ank mutant in complex with rap1
Structure deposition date
2019-09-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
78
Minimum pKa ?
11
% buried
nan
Peptide accession
Q4ACU6
Residue number A
290
Residue number B
298
Peptide name
SH3 and multiple ankyrin repeat domains protein 3
Ligandability
Cysteine 290 of SH3 and multiple ankyrin repeat domains protein 3
Cysteine 298 of SH3 and multiple ankyrin repeat domains protein 3
5g4x A 258 A 298
A redox-regulated disulphide may form within SH3 and multiple ankyrin repeat domains protein 3 between cysteines 258 and 298. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
54
PDB code
5g4x
Structure name
the crystal structure of the shank3 n-terminus
Structure deposition date
2016-05-17
Thiol separation (Å)
5
Half-sphere exposure sum ?
78
Minimum pKa ?
15
% buried
84
Peptide accession
Q9JLU4
Residue number A
258
Residue number B
298
Peptide name
SH3 and multiple ankyrin repeat domains protein 3
Ligandability
Cysteine 258 of SH3 and multiple ankyrin repeat domains protein 3
Cysteine 298 of SH3 and multiple ankyrin repeat domains protein 3
6kyh D 151 D 189
A redox-regulated disulphide may form within SH3 and multiple ankyrin repeat domains protein 3 between cysteines 151 and 189. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
6kyh
Structure name
crystal structure of shank3 ntd-ank a42k mutant in complex with hras
Structure deposition date
2019-09-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
83
Minimum pKa ?
11
% buried
98
Peptide accession
Q4ACU6
Residue number A
151
Residue number B
189
Peptide name
SH3 and multiple ankyrin repeat domains protein 3
Ligandability
Cysteine 151 of SH3 and multiple ankyrin repeat domains protein 3
Cysteine 189 of SH3 and multiple ankyrin repeat domains protein 3
5g4x A 232 A 233
A redox-regulated disulphide may form within SH3 and multiple ankyrin repeat domains protein 3 between cysteines 232 and 233. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
5g4x
Structure name
the crystal structure of the shank3 n-terminus
Structure deposition date
2016-05-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
88
Minimum pKa ?
11
% buried
78
Peptide accession
Q9JLU4
Residue number A
232
Residue number B
233
Peptide name
SH3 and multiple ankyrin repeat domains protein 3
Ligandability
Cysteine 232 of SH3 and multiple ankyrin repeat domains protein 3
Cysteine 233 of SH3 and multiple ankyrin repeat domains protein 3
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