ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Alpha-(1,6)-fucosyltransferase

Intramolecular
Cysteine 204 and cysteine 266
Cysteine 218 and cysteine 222
Cysteine 212 and cysteine 230
Cysteine 465 and cysteine 472
A redox-regulated disulphide may form within Alpha-(1,6)-fucosyltransferase between cysteines 204 and 266.

Details

Redox score ?
88
PDB code
6x5u
Structure name
human alpha-1,6-fucosyltransferase (fut8) bound to gdp and nm5m2-asn
Structure deposition date
2020-05-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9BYC5
Residue number A
204
Residue number B
266
Peptide name
Alpha-(1,6)-fucosyltransferase

Ligandability

Cysteine 204 of Alpha-(1,6)-fucosyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 266 of Alpha-(1,6)-fucosyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Alpha-(1,6)-fucosyltransferase between cysteines 218 and 222.

Details

Redox score ?
83
PDB code
6x5u
Structure name
human alpha-1,6-fucosyltransferase (fut8) bound to gdp and nm5m2-asn
Structure deposition date
2020-05-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9BYC5
Residue number A
218
Residue number B
222
Peptide name
Alpha-(1,6)-fucosyltransferase

Ligandability

Cysteine 218 of Alpha-(1,6)-fucosyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 222 of Alpha-(1,6)-fucosyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Alpha-(1,6)-fucosyltransferase between cysteines 212 and 230.

Details

Redox score ?
80
PDB code
6vld
Structure name
crystal structure of human alpha 1,6-fucosyltransferase, fut8 bound to gdp and a2sgp
Structure deposition date
2020-01-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9BYC5
Residue number A
212
Residue number B
230
Peptide name
Alpha-(1,6)-fucosyltransferase

Ligandability

Cysteine 212 of Alpha-(1,6)-fucosyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 230 of Alpha-(1,6)-fucosyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Alpha-(1,6)-fucosyltransferase between cysteines 465 and 472.

Details

Redox score ?
80
PDB code
6vlf
Structure name
crystal structure of mouse alpha 1,6-fucosyltransferase, fut8 in its apo-form
Structure deposition date
2020-01-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
93
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9WTS2
Residue number A
465
Residue number B
472
Peptide name
Alpha-(1,6)-fucosyltransferase

Ligandability

Cysteine 465 of Alpha-(1,6)-fucosyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 472 of Alpha-(1,6)-fucosyltransferase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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