a tool for identifying drug-targetable redox-active disulphides

39S ribosomal protein L20, mitochondrial

Intermolecular

Cysteine 93 and cysteine 60 of 39S ribosomal protein L42, mitochondrial

A redox-regulated disulphide may form between cysteine 93 of 39S ribosomal protein L20, mitochondrial and cysteine 60 of 39S ribosomal protein L42, mitochondrial. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

28

PDB code

Structure name

structure of a native assembly intermediate of the human mitochondrial ribosome with unfolded interfacial rrna

Structure deposition date

2017-08-08

Thiol separation (Å)

10

Half-sphere exposure sum ?

84

Minimum pK_a ?

11

% buried

100

Peptide A name

39S ribosomal protein L20, mitochondrial

Peptide B name

39S ribosomal protein L42, mitochondrial

Peptide A accession

Peptide B accession

Peptide A residue number

93

Peptide B residue number

60

Ligandability

Cysteine 93 of 39S ribosomal protein L20, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 60 of 39S ribosomal protein L42, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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