a tool for identifying drug-targetable redox-active disulphides

Sulfiredoxin-1

Intermolecular

Cysteine 52 of Peroxiredoxin-1 and cysteine 99

A redox-regulated disulphide may form between cysteine 52 of Peroxiredoxin-1 and cysteine 99 of Sulfiredoxin-1.

Details

Redox score ?

80

PDB code

Structure name

crystal structure of human peroxiredoxin i in complex with sulfiredoxin

Structure deposition date

2007-10-11

Thiol separation (Å)

2

Half-sphere exposure sum ?

75

Minimum pK_a ?

nan

% buried

nan

Peptide A name

Peroxiredoxin-1

Peptide B name

Sulfiredoxin-1

Peptide A accession

Peptide B accession

Peptide A residue number

52

Peptide B residue number

99

Ligandability

Cysteine 52 of Peroxiredoxin-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 99 of Sulfiredoxin-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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