ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Neurolysin, mitochondrial

Intramolecular
Cysteine 255 and cysteine 256
Cysteine 88 and cysteine 153
A redox-regulated disulphide may form within Neurolysin, mitochondrial between cysteines 255 and 256 (232 and 233 respectively in this structure).

Details

Redox score ?
61
PDB code
5lv0
Structure name
structure of human neurolysin (e475q) in complex with amyloid-beta 35- 40 peptide product
Structure deposition date
2016-09-12
Thiol separation (Å)
6
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
56
Peptide accession
Q9BYT8
Residue number A
255
Residue number B
256
Peptide name
Neurolysin, mitochondrial

Ligandability

Cysteine 255 of Neurolysin, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 256 of Neurolysin, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Neurolysin, mitochondrial between cysteines 88 and 153 (65 and 130 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
5lv0
Structure name
structure of human neurolysin (e475q) in complex with amyloid-beta 35- 40 peptide product
Structure deposition date
2016-09-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
36
Peptide accession
Q9BYT8
Residue number A
88
Residue number B
153
Peptide name
Neurolysin, mitochondrial

Ligandability

Cysteine 88 of Neurolysin, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 153 of Neurolysin, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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