ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Transcription regulator protein BACH2

Intermolecular
Cysteine 125 and cysteine 125
Cysteine 20 and cysteine 20
Cysteine 20 and cysteine 58
A redox-regulated disulphide may form between two units of Transcription regulator protein BACH2 at cysteines 125 and 125.

Details

Redox score ?
86
PDB code
3ohv
Structure name
crystal structure of the human bach2 poz domain, form ii
Structure deposition date
2010-08-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide A name
Transcription regulator protein BACH2
Peptide B name
Transcription regulator protein BACH2
Peptide A accession
Q9BYV9
Peptide B accession
Q9BYV9
Peptide A residue number
125
Peptide B residue number
125

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Transcription regulator protein BACH2 at cysteines 20 and 20. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
3ohu
Structure name
crystal structure of the human bach2 poz domain, form i
Structure deposition date
2010-08-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
76
Minimum pKa ?
11
% buried
66
Peptide A name
Transcription regulator protein BACH2
Peptide B name
Transcription regulator protein BACH2
Peptide A accession
Q9BYV9
Peptide B accession
Q9BYV9
Peptide A residue number
20
Peptide B residue number
20

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Transcription regulator protein BACH2 at cysteines 20 and 58. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
3ohu
Structure name
crystal structure of the human bach2 poz domain, form i
Structure deposition date
2010-08-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
77
Minimum pKa ?
11
% buried
80
Peptide A name
Transcription regulator protein BACH2
Peptide B name
Transcription regulator protein BACH2
Peptide A accession
Q9BYV9
Peptide B accession
Q9BYV9
Peptide A residue number
20
Peptide B residue number
58

Ligandability

Cysteine 20 of Transcription regulator protein BACH2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 58 of Transcription regulator protein BACH2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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