ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Interferon-induced helicase C domain-containing protein 1

Intramolecular
Cysteine 907 and cysteine 964
Cysteine 962 and cysteine 964
Cysteine 907 and cysteine 910
Cysteine 907 and cysteine 962
Cysteine 565 and cysteine 600
Cysteine 910 and cysteine 962
Cysteine 910 and cysteine 964
Cysteine 1018 and cysteine 1019
Cysteine 329 and cysteine 511
Cysteine 329 and cysteine 446
More...
Cysteine 328 and cysteine 981
Cysteine 445 and cysteine 510
A redox-regulated disulphide may form within Interferon-induced helicase C domain-containing protein 1 between cysteines 907 and 964.

Details

Redox score ?
85
PDB code
3ga3
Structure name
crystal structure of the c-terminal domain of human mda5
Structure deposition date
2009-02-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
51
Minimum pKa ?
6
% buried
12
Peptide accession
Q9BYX4
Residue number A
907
Residue number B
964
Peptide name
Interferon-induced helicase C domain-containing protein 1

Ligandability

Cysteine 907 of Interferon-induced helicase C domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 964 of Interferon-induced helicase C domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interferon-induced helicase C domain-containing protein 1 between cysteines 962 and 964.

Details

Redox score ?
82
PDB code
6g19
Structure name
cryoem structure of the mda5-dsrna filament with 74-degree helical twist
Structure deposition date
2018-03-20
Thiol separation (Å)
3
Half-sphere exposure sum ?
68
Minimum pKa ?
6
% buried
74
Peptide accession
Q8R5F7
Residue number A
962
Residue number B
964
Peptide name
Interferon-induced helicase C domain-containing protein 1

Ligandability

Cysteine 962 of Interferon-induced helicase C domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 964 of Interferon-induced helicase C domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interferon-induced helicase C domain-containing protein 1 between cysteines 907 and 910.

Details

Redox score ?
80
PDB code
3ga3
Structure name
crystal structure of the c-terminal domain of human mda5
Structure deposition date
2009-02-16
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
7
% buried
12
Peptide accession
Q9BYX4
Residue number A
907
Residue number B
910
Peptide name
Interferon-induced helicase C domain-containing protein 1

Ligandability

Cysteine 907 of Interferon-induced helicase C domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 910 of Interferon-induced helicase C domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interferon-induced helicase C domain-containing protein 1 between cysteines 907 and 962.

Details

Redox score ?
79
PDB code
4gl2
Structure name
structural basis for dsrna duplex backbone recognition by mda5
Structure deposition date
2012-08-13
Thiol separation (Å)
3
Half-sphere exposure sum ?
73
Minimum pKa ?
6
% buried
63
Peptide accession
Q9BYX4
Residue number A
907
Residue number B
962
Peptide name
Interferon-induced helicase C domain-containing protein 1

Ligandability

Cysteine 907 of Interferon-induced helicase C domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 962 of Interferon-induced helicase C domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interferon-induced helicase C domain-containing protein 1 between cysteines 565 and 600.

Details

Redox score ?
79
PDB code
4gl2
Structure name
structural basis for dsrna duplex backbone recognition by mda5
Structure deposition date
2012-08-13
Thiol separation (Å)
3
Half-sphere exposure sum ?
64
Minimum pKa ?
7
% buried
66
Peptide accession
Q9BYX4
Residue number A
565
Residue number B
600
Peptide name
Interferon-induced helicase C domain-containing protein 1

Ligandability

Cysteine 565 of Interferon-induced helicase C domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 600 of Interferon-induced helicase C domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interferon-induced helicase C domain-containing protein 1 between cysteines 910 and 962.

Details

Redox score ?
76
PDB code
4gl2
Structure name
structural basis for dsrna duplex backbone recognition by mda5
Structure deposition date
2012-08-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
6
% buried
50
Peptide accession
Q9BYX4
Residue number A
910
Residue number B
962
Peptide name
Interferon-induced helicase C domain-containing protein 1

Ligandability

Cysteine 910 of Interferon-induced helicase C domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 962 of Interferon-induced helicase C domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interferon-induced helicase C domain-containing protein 1 between cysteines 910 and 964.

Details

Redox score ?
75
PDB code
4gl2
Structure name
structural basis for dsrna duplex backbone recognition by mda5
Structure deposition date
2012-08-13
Thiol separation (Å)
3
Half-sphere exposure sum ?
60
Minimum pKa ?
9
% buried
48
Peptide accession
Q9BYX4
Residue number A
910
Residue number B
964
Peptide name
Interferon-induced helicase C domain-containing protein 1

Ligandability

Cysteine 910 of Interferon-induced helicase C domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 964 of Interferon-induced helicase C domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interferon-induced helicase C domain-containing protein 1 between cysteines 1018 and 1019. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
60
PDB code
2rqb
Structure name
solution structure of mda5 ctd
Structure deposition date
2009-03-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
25
Minimum pKa ?
9
% buried
0
Peptide accession
Q9BYX4
Residue number A
1018
Residue number B
1019
Peptide name
Interferon-induced helicase C domain-containing protein 1

Ligandability

Cysteine 1018 of Interferon-induced helicase C domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1019 of Interferon-induced helicase C domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interferon-induced helicase C domain-containing protein 1 between cysteines 329 and 511. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
7bkp
Structure name
cryoem structure of disease related m854k mda5-dsrna filament in complex with atp
Structure deposition date
2021-01-16
Thiol separation (Å)
8
Half-sphere exposure sum ?
75
Minimum pKa ?
11
% buried
99
Peptide accession
Q8R5F7
Residue number A
329
Residue number B
511
Peptide name
Interferon-induced helicase C domain-containing protein 1

Ligandability

Cysteine 329 of Interferon-induced helicase C domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 511 of Interferon-induced helicase C domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interferon-induced helicase C domain-containing protein 1 between cysteines 329 and 446. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
6h66
Structure name
cryoem structure of the mda5-dsrna filament with 93 degree twist and without nucleotide
Structure deposition date
2018-07-26
Thiol separation (Å)
10
Half-sphere exposure sum ?
75
Minimum pKa ?
11
% buried
100
Peptide accession
Q8R5F7
Residue number A
329
Residue number B
446
Peptide name
Interferon-induced helicase C domain-containing protein 1

Ligandability

Cysteine 329 of Interferon-induced helicase C domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 446 of Interferon-induced helicase C domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Interferon-induced helicase C domain-containing protein 1 between cysteines 328 and 981 (328 and 333 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
4gl2
Structure name
structural basis for dsrna duplex backbone recognition by mda5
Structure deposition date
2012-08-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
75
Minimum pKa ?
12
% buried
90
Peptide accession
Q9BYX4
Residue number A
328
Residue number B
981
Peptide name
Interferon-induced helicase C domain-containing protein 1

Ligandability

Cysteine 328 of Interferon-induced helicase C domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 981 of Interferon-induced helicase C domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Uncertain whether structure cysteine 333 has been assigned to correct residue.
A redox-regulated disulphide may form within Interferon-induced helicase C domain-containing protein 1 between cysteines 445 and 510. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
4gl2
Structure name
structural basis for dsrna duplex backbone recognition by mda5
Structure deposition date
2012-08-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
86
Minimum pKa ?
11
% buried
99
Peptide accession
Q9BYX4
Residue number A
445
Residue number B
510
Peptide name
Interferon-induced helicase C domain-containing protein 1

Ligandability

Cysteine 445 of Interferon-induced helicase C domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 510 of Interferon-induced helicase C domain-containing protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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