ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Regenerating islet-derived protein 4

Intramolecular
Cysteine 30 and cysteine 41
Cysteine 58 and cysteine 154
Cysteine 129 and cysteine 146
Cysteine 41 and cysteine 154
A redox-regulated disulphide may form within Regenerating islet-derived protein 4 between cysteines 30 and 41 (3 and 14 respectively in this structure).

Details

Redox score ?
86
PDB code
2kv3
Structure name
human regenerating gene type iv (reg iv) protein, p91s mutant
Structure deposition date
2010-03-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9BYZ8
Residue number A
30
Residue number B
41
Peptide name
Regenerating islet-derived protein 4

Ligandability

Cysteine 30 of Regenerating islet-derived protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 41 of Regenerating islet-derived protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Regenerating islet-derived protein 4 between cysteines 58 and 154 (31 and 127 respectively in this structure).

Details

Redox score ?
85
PDB code
2kv3
Structure name
human regenerating gene type iv (reg iv) protein, p91s mutant
Structure deposition date
2010-03-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9BYZ8
Residue number A
58
Residue number B
154
Peptide name
Regenerating islet-derived protein 4

Ligandability

Cysteine 58 of Regenerating islet-derived protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 154 of Regenerating islet-derived protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Regenerating islet-derived protein 4 between cysteines 129 and 146 (102 and 119 respectively in this structure).

Details

Redox score ?
84
PDB code
2kv3
Structure name
human regenerating gene type iv (reg iv) protein, p91s mutant
Structure deposition date
2010-03-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9BYZ8
Residue number A
129
Residue number B
146
Peptide name
Regenerating islet-derived protein 4

Ligandability

Cysteine 129 of Regenerating islet-derived protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 146 of Regenerating islet-derived protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Regenerating islet-derived protein 4 between cysteines 41 and 154 (14 and 127 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
2kv3
Structure name
human regenerating gene type iv (reg iv) protein, p91s mutant
Structure deposition date
2010-03-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9BYZ8
Residue number A
41
Residue number B
154
Peptide name
Regenerating islet-derived protein 4

Ligandability

Cysteine 41 of Regenerating islet-derived protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 154 of Regenerating islet-derived protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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