a tool for identifying drug-targetable redox-active disulphides

Dedicator of cytokinesis protein 9

Intramolecular

Cysteine 1966 and cysteine 2027

A redox-regulated disulphide may form within Dedicator of cytokinesis protein 9 between cysteines 1966 and 2027 (325 and 386 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

39

PDB code

Structure name

structure of the complex between dock9 and cdc42

Structure deposition date

2009-07-02

Thiol separation (Å)

9

Half-sphere exposure sum ?

71

Minimum pK_a ?

10

% buried

66

Peptide accession

Residue number A

1966

Residue number B

2027

Peptide name

Dedicator of cytokinesis protein 9

Ligandability

Cysteine 1966 of Dedicator of cytokinesis protein 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2027 of Dedicator of cytokinesis protein 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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