ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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F-box-like/WD repeat-containing protein TBL1XR1

Intermolecular
Cysteine 330 and cysteine 434
Intramolecular
Cysteine 175 and cysteine 490
Cysteine 325 and cysteine 367
Cysteine 175 and cysteine 508
A redox-regulated disulphide may form between two units of F-box-like/WD repeat-containing protein TBL1XR1 at cysteines 330 and 434. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
5naf
Structure name
co-crystal structure of an mecp2 peptide with tblr1 wd40 domain
Structure deposition date
2017-02-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
76
Minimum pKa ?
9
% buried
100
Peptide A name
F-box-like/WD repeat-containing protein TBL1XR1
Peptide B name
F-box-like/WD repeat-containing protein TBL1XR1
Peptide A accession
Q8BHJ5
Peptide B accession
Q8BHJ5
Peptide A residue number
330
Peptide B residue number
434

Ligandability

Cysteine 330 of F-box-like/WD repeat-containing protein TBL1XR1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 434 of F-box-like/WD repeat-containing protein TBL1XR1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within F-box-like/WD repeat-containing protein TBL1XR1 between cysteines 175 and 490.

Details

Redox score ?
69
PDB code
4lg9
Structure name
crystal structure of tbl1xr1 wd40 repeats
Structure deposition date
2013-06-27
Thiol separation (Å)
4
Half-sphere exposure sum ?
90
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9BZK7
Residue number A
175
Residue number B
490
Peptide name
F-box-like/WD repeat-containing protein TBL1XR1

Ligandability

Cysteine 175 of F-box-like/WD repeat-containing protein TBL1XR1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 490 of F-box-like/WD repeat-containing protein TBL1XR1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within F-box-like/WD repeat-containing protein TBL1XR1 between cysteines 325 and 367. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
4lg9
Structure name
crystal structure of tbl1xr1 wd40 repeats
Structure deposition date
2013-06-27
Thiol separation (Å)
8
Half-sphere exposure sum ?
96
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9BZK7
Residue number A
325
Residue number B
367
Peptide name
F-box-like/WD repeat-containing protein TBL1XR1

Ligandability

Cysteine 325 of F-box-like/WD repeat-containing protein TBL1XR1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 367 of F-box-like/WD repeat-containing protein TBL1XR1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within F-box-like/WD repeat-containing protein TBL1XR1 between cysteines 175 and 508. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
4lg9
Structure name
crystal structure of tbl1xr1 wd40 repeats
Structure deposition date
2013-06-27
Thiol separation (Å)
10
Half-sphere exposure sum ?
94
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9BZK7
Residue number A
175
Residue number B
508
Peptide name
F-box-like/WD repeat-containing protein TBL1XR1

Ligandability

Cysteine 175 of F-box-like/WD repeat-containing protein TBL1XR1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 508 of F-box-like/WD repeat-containing protein TBL1XR1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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