ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Reticulon-4 receptor

Intramolecular
Cysteine 27 and cysteine 33
Cysteine 266 and cysteine 473
Cysteine 266 and cysteine 309
Cysteine 31 and cysteine 43
Cysteine 264 and cysteine 287
Cysteine 309 and cysteine 336
Cysteine 266 and cysteine 335
Cysteine 335 and cysteine 473
Cysteine 266 and cysteine 336
Cysteine 31 and cysteine 33
More...
Cysteine 27 and cysteine 31
Cysteine 335 and cysteine 336
Cysteine 309 and cysteine 473
Cysteine 27 and cysteine 43
Cysteine 33 and cysteine 43
Cysteine 309 and cysteine 335
A redox-regulated disulphide may form within Reticulon-4 receptor between cysteines 27 and 33.

Details

Redox score ?
90
PDB code
1p8t
Structure name
crystal structure of nogo-66 receptor
Structure deposition date
2003-05-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9BZR6
Residue number A
27
Residue number B
33
Peptide name
Reticulon-4 receptor

Ligandability

Cysteine 27 of Reticulon-4 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 33 of Reticulon-4 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Reticulon-4 receptor between cysteines 266 and 473 (266 and 309 respectively in this structure).

Details

Redox score ?
88
PDB code
1ozn
Structure name
1
Structure deposition date
2003-04-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9BZR6
Residue number A
266
Residue number B
473
Peptide name
Reticulon-4 receptor

Ligandability

Cysteine 266 of Reticulon-4 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 473 of Reticulon-4 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Reticulon-4 receptor between cysteines 266 and 309.

Details

Redox score ?
88
PDB code
1p8t
Structure name
crystal structure of nogo-66 receptor
Structure deposition date
2003-05-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
38
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9BZR6
Residue number A
266
Residue number B
309
Peptide name
Reticulon-4 receptor

Ligandability

Cysteine 266 of Reticulon-4 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 309 of Reticulon-4 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Reticulon-4 receptor between cysteines 31 and 43.

Details

Redox score ?
87
PDB code
5o0p
Structure name
deglycosylated nogo receptor with native disulfide structure 6
Structure deposition date
2017-05-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99PI8
Residue number A
31
Residue number B
43
Peptide name
Reticulon-4 receptor

Ligandability

Cysteine 31 of Reticulon-4 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 43 of Reticulon-4 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Reticulon-4 receptor between cysteines 264 and 287.

Details

Redox score ?
84
PDB code
1p8t
Structure name
crystal structure of nogo-66 receptor
Structure deposition date
2003-05-07
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9BZR6
Residue number A
264
Residue number B
287
Peptide name
Reticulon-4 receptor

Ligandability

Cysteine 264 of Reticulon-4 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 287 of Reticulon-4 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Reticulon-4 receptor between cysteines 309 and 336.

Details

Redox score ?
84
PDB code
5o0o
Structure name
deglycosylated nogo receptor with native disulfide structure 5
Structure deposition date
2017-05-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99PI8
Residue number A
309
Residue number B
336
Peptide name
Reticulon-4 receptor

Ligandability

Cysteine 309 of Reticulon-4 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 336 of Reticulon-4 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Reticulon-4 receptor between cysteines 266 and 335.

Details

Redox score ?
82
PDB code
5o0n
Structure name
deglycosylated nogo receptor with native disulfide structure 4
Structure deposition date
2017-05-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99PI8
Residue number A
266
Residue number B
335
Peptide name
Reticulon-4 receptor

Ligandability

Cysteine 266 of Reticulon-4 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 335 of Reticulon-4 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Reticulon-4 receptor between cysteines 335 and 473 (335 and 336 respectively in this structure).

Details

Redox score ?
77
PDB code
5o0l
Structure name
deglycosylated nogo receptor with native disulfide structure 2
Structure deposition date
2017-05-16
Thiol separation (Å)
5
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99PI8
Residue number A
335
Residue number B
473
Peptide name
Reticulon-4 receptor

Ligandability

Cysteine 335 of Reticulon-4 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 473 of Reticulon-4 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Reticulon-4 receptor between cysteines 266 and 336.

Details

Redox score ?
70
PDB code
5o0m
Structure name
deglycosylated nogo receptor with native disulfide structure 3
Structure deposition date
2017-05-16
Thiol separation (Å)
5
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99PI8
Residue number A
266
Residue number B
336
Peptide name
Reticulon-4 receptor

Ligandability

Cysteine 266 of Reticulon-4 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 336 of Reticulon-4 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Reticulon-4 receptor between cysteines 31 and 33.

Details

Redox score ?
68
PDB code
1p8t
Structure name
crystal structure of nogo-66 receptor
Structure deposition date
2003-05-07
Thiol separation (Å)
6
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9BZR6
Residue number A
31
Residue number B
33
Peptide name
Reticulon-4 receptor

Ligandability

Cysteine 31 of Reticulon-4 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 33 of Reticulon-4 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Reticulon-4 receptor between cysteines 27 and 31.

Details

Redox score ?
67
PDB code
7r86
Structure name
structure of mouse bai1 (adgrb1) in complex with mouse nogo receptor (rtn4r)
Structure deposition date
2021-06-26
Thiol separation (Å)
5
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99PI8
Residue number A
27
Residue number B
31
Peptide name
Reticulon-4 receptor

Ligandability

Cysteine 27 of Reticulon-4 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 31 of Reticulon-4 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Reticulon-4 receptor between cysteines 335 and 336.

Details

Redox score ?
64
PDB code
5o0n
Structure name
deglycosylated nogo receptor with native disulfide structure 4
Structure deposition date
2017-05-16
Thiol separation (Å)
6
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99PI8
Residue number A
335
Residue number B
336
Peptide name
Reticulon-4 receptor

Ligandability

Cysteine 335 of Reticulon-4 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 336 of Reticulon-4 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Reticulon-4 receptor between cysteines 309 and 473 (309 and 335 respectively in this structure).

Details

Redox score ?
63
PDB code
5o0p
Structure name
deglycosylated nogo receptor with native disulfide structure 6
Structure deposition date
2017-05-16
Thiol separation (Å)
6
Half-sphere exposure sum ?
35
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99PI8
Residue number A
309
Residue number B
473
Peptide name
Reticulon-4 receptor

Ligandability

Cysteine 309 of Reticulon-4 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 473 of Reticulon-4 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Reticulon-4 receptor between cysteines 27 and 43. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
60
PDB code
1ozn
Structure name
1
Structure deposition date
2003-04-09
Thiol separation (Å)
6
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9BZR6
Residue number A
27
Residue number B
43
Peptide name
Reticulon-4 receptor

Ligandability

Cysteine 27 of Reticulon-4 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 43 of Reticulon-4 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Reticulon-4 receptor between cysteines 33 and 43. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
59
PDB code
1ozn
Structure name
1
Structure deposition date
2003-04-09
Thiol separation (Å)
7
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9BZR6
Residue number A
33
Residue number B
43
Peptide name
Reticulon-4 receptor

Ligandability

Cysteine 33 of Reticulon-4 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 43 of Reticulon-4 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Reticulon-4 receptor between cysteines 309 and 335. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
5o0o
Structure name
deglycosylated nogo receptor with native disulfide structure 5
Structure deposition date
2017-05-16
Thiol separation (Å)
6
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q99PI8
Residue number A
309
Residue number B
335
Peptide name
Reticulon-4 receptor

Ligandability

Cysteine 309 of Reticulon-4 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 335 of Reticulon-4 receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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