ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Sialoadhesin

Intermolecular
Cysteine 36 and cysteine 36
Intramolecular
Cysteine 41 and cysteine 98
A redox-regulated disulphide may form between two units of Sialoadhesin at cysteines 36 and 36 (17 and 17 respectively in this structure).

Details

Redox score ?
80
PDB code
2bve
Structure name
structure of the n-terminal of sialoadhesin in complex with 2-phenyl- prop5ac
Structure deposition date
2005-06-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide A name
Sialoadhesin
Peptide B name
Sialoadhesin
Peptide A accession
Q62230
Peptide B accession
Q62230
Peptide A residue number
36
Peptide B residue number
36

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sialoadhesin between cysteines 41 and 98 (22 and 79 respectively in this structure).

Details

Redox score ?
85
PDB code
1oda
Structure name
n-terminal of sialoadhesin in complex with me-a-9-n- (biphenyl-4-carbonyl)-amino-9-deoxy-neu5ac (bip compound)
Structure deposition date
2003-02-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q62230
Residue number A
41
Residue number B
98
Peptide name
Sialoadhesin

Ligandability

Cysteine 41 of Sialoadhesin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 98 of Sialoadhesin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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