ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Apoptosis inhibitor 5

Intramolecular
Cysteine 263 and cysteine 297
Cysteine 234 and cysteine 241
A redox-regulated disulphide may form within Apoptosis inhibitor 5 between cysteines 263 and 297. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
6l4o
Structure name
crystal structure of api5-fgf2 complex
Structure deposition date
2019-10-18
Thiol separation (Å)
7
Half-sphere exposure sum ?
76
Minimum pKa ?
11
% buried
88
Peptide accession
Q9BZZ5
Residue number A
263
Residue number B
297
Peptide name
Apoptosis inhibitor 5

Ligandability

Cysteine 263 of Apoptosis inhibitor 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 297 of Apoptosis inhibitor 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Apoptosis inhibitor 5 between cysteines 234 and 241. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
3v6a
Structure name
helical repeat structure of apoptosis inhibitor 5 reveals protein- protein interaction modules
Structure deposition date
2011-12-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
58
Minimum pKa ?
9
% buried
44
Peptide accession
Q9BZZ5
Residue number A
234
Residue number B
241
Peptide name
Apoptosis inhibitor 5

Ligandability

Cysteine 234 of Apoptosis inhibitor 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 241 of Apoptosis inhibitor 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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