E3 ubiquitin-protein ligase TRIM7

Intermolecular

A redox-regulated disulphide may form between two units of E3 ubiquitin-protein ligase TRIM7 at cysteines 378 and 378 (37 and 37 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

7ow2

Structure name

e3 ring ligase binding domain with peptide

Structure deposition date

2021-06-16

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide A name

E3 ubiquitin-protein ligase TRIM7

Peptide B name

E3 ubiquitin-protein ligase TRIM7

Peptide A accession

Q9C029

Peptide B accession

Q9C029

Peptide A residue number

378

Peptide B residue number

378

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of E3 ubiquitin-protein ligase TRIM7 at cysteines 378 and 455 (37 and 114 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

8a8x

Structure name

trim7 pryspry in complex with a mnv1-ns3 peptide hddfglq

Structure deposition date

2022-06-24

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide A name

E3 ubiquitin-protein ligase TRIM7

Peptide B name

E3 ubiquitin-protein ligase TRIM7

Peptide A accession

Q9C029

Peptide B accession

Q9C029

Peptide A residue number

378

Peptide B residue number

455

Ligandability

Cysteine 378 of E3 ubiquitin-protein ligase TRIM7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 455 of E3 ubiquitin-protein ligase TRIM7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of E3 ubiquitin-protein ligase TRIM7 at cysteines 390 and 455 (49 and 114 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?