a tool for identifying drug-targetable redox-active disulphides

Protein zyg-11 homolog B

Intramolecular

Cysteine 678 and cysteine 686

A redox-regulated disulphide may form within Protein zyg-11 homolog B between cysteines 678 and 686.

Details

Redox score ?

70

PDB code

Structure name

crystal structure of zyg11b bound to ggfn degron

Structure deposition date

2021-04-26

Thiol separation (Å)

4

Half-sphere exposure sum ?

66

Minimum pK_a ?

10

% buried

52

Peptide accession

Residue number A

678

Residue number B

686

Peptide name

Protein zyg-11 homolog B

Ligandability

Cysteine 678 of Protein zyg-11 homolog B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 686 of Protein zyg-11 homolog B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: