ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Exportin-4

Intramolecular
Cysteine 134 and cysteine 186
Cysteine 1022 and cysteine 1025
Cysteine 380 and cysteine 439 L
Cysteine 988 and cysteine 1025
Cysteine 977 and cysteine 1025
Cysteine 813 and cysteine 838
A redox-regulated disulphide may form within Exportin-4 between cysteines 134 and 186. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
5dlq
Structure name
crystal structure of rangtp-exportin 4-eif5a complex
Structure deposition date
2015-09-07
Thiol separation (Å)
7
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
60
Peptide accession
Q9ESJ0
Residue number A
134
Residue number B
186
Peptide name
Exportin-4

Ligandability

Cysteine 134 of Exportin-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 186 of Exportin-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Exportin-4 between cysteines 1022 and 1025. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
5dlq
Structure name
crystal structure of rangtp-exportin 4-eif5a complex
Structure deposition date
2015-09-07
Thiol separation (Å)
7
Half-sphere exposure sum ?
77
Minimum pKa ?
10
% buried
62
Peptide accession
Q9ESJ0
Residue number A
1022
Residue number B
1025
Peptide name
Exportin-4

Ligandability

Cysteine 1022 of Exportin-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1025 of Exportin-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Exportin-4 between cysteines 380 and 439. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
5dlq
Structure name
crystal structure of rangtp-exportin 4-eif5a complex
Structure deposition date
2015-09-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
69
Minimum pKa ?
10
% buried
72
Peptide accession
Q9ESJ0
Residue number A
380
Residue number B
439
Peptide name
Exportin-4

Ligandability

Cysteine 380 of Exportin-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 439 of Exportin-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Exportin-4 between cysteines 988 and 1025. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
5dlq
Structure name
crystal structure of rangtp-exportin 4-eif5a complex
Structure deposition date
2015-09-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
11
% buried
73
Peptide accession
Q9ESJ0
Residue number A
988
Residue number B
1025
Peptide name
Exportin-4

Ligandability

Cysteine 988 of Exportin-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1025 of Exportin-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Exportin-4 between cysteines 977 and 1025. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
5dlq
Structure name
crystal structure of rangtp-exportin 4-eif5a complex
Structure deposition date
2015-09-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
11
% buried
80
Peptide accession
Q9ESJ0
Residue number A
977
Residue number B
1025
Peptide name
Exportin-4

Ligandability

Cysteine 977 of Exportin-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1025 of Exportin-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Exportin-4 between cysteines 813 and 838. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
5dlq
Structure name
crystal structure of rangtp-exportin 4-eif5a complex
Structure deposition date
2015-09-07
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
12
% buried
96
Peptide accession
Q9ESJ0
Residue number A
813
Residue number B
838
Peptide name
Exportin-4

Ligandability

Cysteine 813 of Exportin-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 838 of Exportin-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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