a tool for identifying drug-targetable redox-active disulphides

Glutamate receptor-interacting protein 2

Intramolecular

Cysteine 460 and cysteine 499

A redox-regulated disulphide may form within Glutamate receptor-interacting protein 2 between cysteines 460 and 499 (22 and 61 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

38

PDB code

Structure name

solution structure of the fourth pdz domain of glutamate receptor interacting protein 2

Structure deposition date

2005-05-16

Thiol separation (Å)

10

Half-sphere exposure sum ?

53

Minimum pK_a ?

9

% buried

8

Peptide accession

Residue number A

460

Residue number B

499

Peptide name

Glutamate receptor-interacting protein 2

Ligandability

Cysteine 460 of Glutamate receptor-interacting protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 499 of Glutamate receptor-interacting protein 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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