ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Protein tweety homolog 3

Intramolecular
Cysteine 299 and cysteine 366
Cysteine 271 and cysteine 381
Cysteine 97 and cysteine 224
Cysteine 89 and cysteine 407
Cysteine 243 and cysteine 407
A redox-regulated disulphide may form within Protein tweety homolog 3 between cysteines 299 and 366.

Details

Redox score ?
83
PDB code
7p5c
Structure name
cryo-em structure of human ttyh3 in ca2+ and gdn
Structure deposition date
2021-07-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9C0H2
Residue number A
299
Residue number B
366
Peptide name
Protein tweety homolog 3

Ligandability

Cysteine 299 of Protein tweety homolog 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 366 of Protein tweety homolog 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein tweety homolog 3 between cysteines 271 and 381.

Details

Redox score ?
80
PDB code
7p5c
Structure name
cryo-em structure of human ttyh3 in ca2+ and gdn
Structure deposition date
2021-07-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9C0H2
Residue number A
271
Residue number B
381
Peptide name
Protein tweety homolog 3

Ligandability

Cysteine 271 of Protein tweety homolog 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 381 of Protein tweety homolog 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein tweety homolog 3 between cysteines 97 and 224.

Details

Redox score ?
71
PDB code
7p5c
Structure name
cryo-em structure of human ttyh3 in ca2+ and gdn
Structure deposition date
2021-07-14
Thiol separation (Å)
4
Half-sphere exposure sum ?
83
Minimum pKa ?
9
% buried
90
Peptide accession
Q9C0H2
Residue number A
97
Residue number B
224
Peptide name
Protein tweety homolog 3

Ligandability

Cysteine 97 of Protein tweety homolog 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 224 of Protein tweety homolog 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein tweety homolog 3 between cysteines 89 and 407. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
7p5c
Structure name
cryo-em structure of human ttyh3 in ca2+ and gdn
Structure deposition date
2021-07-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
58
Minimum pKa ?
9
% buried
18
Peptide accession
Q9C0H2
Residue number A
89
Residue number B
407
Peptide name
Protein tweety homolog 3

Ligandability

Cysteine 89 of Protein tweety homolog 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 407 of Protein tweety homolog 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Protein tweety homolog 3 between cysteines 243 and 407. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
7p5c
Structure name
cryo-em structure of human ttyh3 in ca2+ and gdn
Structure deposition date
2021-07-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
10
% buried
46
Peptide accession
Q9C0H2
Residue number A
243
Residue number B
407
Peptide name
Protein tweety homolog 3

Ligandability

Cysteine 243 of Protein tweety homolog 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 407 of Protein tweety homolog 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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