ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ig-like domain-containing protein

Intramolecular
Cysteine 41 and cysteine 115
Cysteine 165 and cysteine 220
A redox-regulated disulphide may form within Ig-like domain-containing protein between cysteines 41 and 115 (22 and 92 respectively in this structure).

Details

Redox score ?
80
PDB code
4nj9
Structure name
crystal structure of fab 8b10 in complex with mpts
Structure deposition date
2013-11-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9D8L4
Residue number A
41
Residue number B
115
Peptide name
Ig-like domain-containing protein

Ligandability

Cysteine 41 of Ig-like domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 115 of Ig-like domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ig-like domain-containing protein between cysteines 165 and 220 (142 and 208 respectively in this structure).

Details

Redox score ?
79
PDB code
4nj9
Structure name
crystal structure of fab 8b10 in complex with mpts
Structure deposition date
2013-11-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9D8L4
Residue number A
165
Residue number B
220
Peptide name
Ig-like domain-containing protein

Ligandability

Cysteine 165 of Ig-like domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 220 of Ig-like domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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