ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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16L protein

Intermolecular
Cysteine 61 and cysteine 62 of Apoptosis regulator BAX L
A redox-regulated disulphide may form between cysteine 61 of 16L protein and cysteine 62 of Apoptosis regulator BAX (61 and 160 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
6trr
Structure name
structural insight into tanapoxvirus mediated inhibition of apoptosis
Structure deposition date
2019-12-19
Thiol separation (Å)
10
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
45
Peptide A name
16L protein
Peptide B name
Apoptosis regulator BAX
Peptide A accession
Q9DHU6
Peptide B accession
Q07812
Peptide A residue number
61
Peptide B residue number
62

Ligandability

Cysteine 61 of 16L protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 62 of Apoptosis regulator BAX

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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