ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Major histocompatibility complex class I

Intramolecular
Cysteine 124 and cysteine 187
Cysteine 226 and cysteine 282
A redox-regulated disulphide may form within Major histocompatibility complex class I between cysteines 124 and 187 (101 and 164 respectively in this structure).

Details

Redox score ?
83
PDB code
3rwc
Structure name
crystal structure of rhesus macaque mhc class i molecule mamu-b*17-iw9
Structure deposition date
2011-05-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9GJ77
Residue number A
124
Residue number B
187
Peptide name
Major histocompatibility complex class I

Ligandability

Cysteine 124 of Major histocompatibility complex class I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 187 of Major histocompatibility complex class I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Major histocompatibility complex class I between cysteines 226 and 282 (203 and 259 respectively in this structure).

Details

Redox score ?
79
PDB code
3rwh
Structure name
rhesus macaque mhc class i molecule mamu-b*17-mf8
Structure deposition date
2011-05-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9GJ77
Residue number A
226
Residue number B
282
Peptide name
Major histocompatibility complex class I

Ligandability

Cysteine 226 of Major histocompatibility complex class I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 282 of Major histocompatibility complex class I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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