ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Skeletal muscle myosin heavy chain MyHC-EO/IIL

Intramolecular
Cysteine 402 and cysteine 403
Cysteine 123 and cysteine 676
A redox-regulated disulphide may form within Skeletal muscle myosin heavy chain MyHC-EO/IIL between cysteines 402 and 403. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
60
PDB code
5h53
Structure name
the structure of rabbit skeletal muscle actomyosin rigor complex at 5
Structure deposition date
2016-11-04
Thiol separation (Å)
5
Half-sphere exposure sum ?
68
Minimum pKa ?
10
% buried
40
Peptide accession
Q9GJP9
Residue number A
402
Residue number B
403
Peptide name
Skeletal muscle myosin heavy chain MyHC-EO/IIL

Ligandability

Cysteine 402 of Skeletal muscle myosin heavy chain MyHC-EO/IIL

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 403 of Skeletal muscle myosin heavy chain MyHC-EO/IIL

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Skeletal muscle myosin heavy chain MyHC-EO/IIL between cysteines 123 and 676. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
5h53
Structure name
the structure of rabbit skeletal muscle actomyosin rigor complex at 5
Structure deposition date
2016-11-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
11
% buried
89
Peptide accession
Q9GJP9
Residue number A
123
Residue number B
676
Peptide name
Skeletal muscle myosin heavy chain MyHC-EO/IIL

Ligandability

Cysteine 123 of Skeletal muscle myosin heavy chain MyHC-EO/IIL

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 676 of Skeletal muscle myosin heavy chain MyHC-EO/IIL

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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