Probable G-protein coupled receptor 88
Intramolecular
Cysteine 325 and cysteine 326
Cysteine 290 and cysteine 291
Cysteine 132 and cysteine 211
Cysteine 81 and cysteine 326
Cysteine 211 and cysteine 290
Cysteine 74 and cysteine 81
7ejx R 325 R 326
A redox-regulated disulphide may form within Probable G-protein coupled receptor 88 between cysteines 325 and 326. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
7ejx
Structure name
structure of the gpr88-gi1 signaling complex bound to a synthetic ligand
Structure deposition date
2021-04-02
Thiol separation (Å)
6
Half-sphere exposure sum ?
79
Minimum pKa ?
12
% buried
89
Peptide accession
Q9GZN0
Residue number A
325
Residue number B
326
Peptide name
Probable G-protein coupled receptor 88
Ligandability
Cysteine 325 of Probable G-protein coupled receptor 88
Cysteine 326 of Probable G-protein coupled receptor 88
7ejx R 290 R 291
A redox-regulated disulphide may form within Probable G-protein coupled receptor 88 between cysteines 290 and 291. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
7ejx
Structure name
structure of the gpr88-gi1 signaling complex bound to a synthetic ligand
Structure deposition date
2021-04-02
Thiol separation (Å)
7
Half-sphere exposure sum ?
51
Minimum pKa ?
11
% buried
71
Peptide accession
Q9GZN0
Residue number A
290
Residue number B
291
Peptide name
Probable G-protein coupled receptor 88
Ligandability
Cysteine 290 of Probable G-protein coupled receptor 88
Cysteine 291 of Probable G-protein coupled receptor 88
7wz4 R 132 R 211
A redox-regulated disulphide may form within Probable G-protein coupled receptor 88 between cysteines 132 and 211. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
7wz4
Structure name
structure of an orphan gpcr-g protein signaling complex
Structure deposition date
2022-02-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
63
Minimum pKa ?
11
% buried
54
Peptide accession
Q9GZN0
Residue number A
132
Residue number B
211
Peptide name
Probable G-protein coupled receptor 88
Ligandability
Cysteine 132 of Probable G-protein coupled receptor 88
Cysteine 211 of Probable G-protein coupled receptor 88
7wz4 R 81 R 326
A redox-regulated disulphide may form within Probable G-protein coupled receptor 88 between cysteines 81 and 326. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
7wz4
Structure name
structure of an orphan gpcr-g protein signaling complex
Structure deposition date
2022-02-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
88
Minimum pKa ?
10
% buried
47
Peptide accession
Q9GZN0
Residue number A
81
Residue number B
326
Peptide name
Probable G-protein coupled receptor 88
Ligandability
Cysteine 81 of Probable G-protein coupled receptor 88
Cysteine 326 of Probable G-protein coupled receptor 88
7wz4 R 211 R 290
A redox-regulated disulphide may form within Probable G-protein coupled receptor 88 between cysteines 211 and 290. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
35
PDB code
7wz4
Structure name
structure of an orphan gpcr-g protein signaling complex
Structure deposition date
2022-02-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
58
Minimum pKa ?
11
% buried
48
Peptide accession
Q9GZN0
Residue number A
211
Residue number B
290
Peptide name
Probable G-protein coupled receptor 88
Ligandability
Cysteine 211 of Probable G-protein coupled receptor 88
Cysteine 290 of Probable G-protein coupled receptor 88
7ejx R 74 R 81
A redox-regulated disulphide may form within Probable G-protein coupled receptor 88 between cysteines 74 and 81. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
7ejx
Structure name
structure of the gpr88-gi1 signaling complex bound to a synthetic ligand
Structure deposition date
2021-04-02
Thiol separation (Å)
9
Half-sphere exposure sum ?
87
Minimum pKa ?
12
% buried
81
Peptide accession
Q9GZN0
Residue number A
74
Residue number B
81
Peptide name
Probable G-protein coupled receptor 88
Ligandability
Cysteine 74 of Probable G-protein coupled receptor 88
Cysteine 81 of Probable G-protein coupled receptor 88
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