ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Actin-related protein 6

Intermolecular
Cysteine 206 of RuvB-like 1 and cysteine 339
Intramolecular
Cysteine 144 and cysteine 161
Cysteine 144 and cysteine 145
Cysteine 145 and cysteine 161
A redox-regulated disulphide may form between cysteine 206 of RuvB-like 1 and cysteine 339 of Actin-related protein 6. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
6igm
Structure name
cryo-em structure of human srcap complex
Structure deposition date
2018-09-25
Thiol separation (Å)
8
Half-sphere exposure sum ?
57
Minimum pKa ?
11
% buried
59
Peptide A name
RuvB-like 1
Peptide B name
Actin-related protein 6
Peptide A accession
Q9Y265
Peptide B accession
Q9GZN1
Peptide A residue number
206
Peptide B residue number
339

Ligandability

Cysteine 206 of RuvB-like 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 339 of Actin-related protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Actin-related protein 6 between cysteines 144 and 161.

Details

Redox score ?
70
PDB code
6igm
Structure name
cryo-em structure of human srcap complex
Structure deposition date
2018-09-25
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
10
% buried
54
Peptide accession
Q9GZN1
Residue number A
144
Residue number B
161
Peptide name
Actin-related protein 6

Ligandability

Cysteine 144 of Actin-related protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 161 of Actin-related protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Actin-related protein 6 between cysteines 144 and 145. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
6igm
Structure name
cryo-em structure of human srcap complex
Structure deposition date
2018-09-25
Thiol separation (Å)
6
Half-sphere exposure sum ?
78
Minimum pKa ?
12
% buried
80
Peptide accession
Q9GZN1
Residue number A
144
Residue number B
145
Peptide name
Actin-related protein 6

Ligandability

Cysteine 144 of Actin-related protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 145 of Actin-related protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Actin-related protein 6 between cysteines 145 and 161. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
6igm
Structure name
cryo-em structure of human srcap complex
Structure deposition date
2018-09-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
10
% buried
59
Peptide accession
Q9GZN1
Residue number A
145
Residue number B
161
Peptide name
Actin-related protein 6

Ligandability

Cysteine 145 of Actin-related protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 161 of Actin-related protein 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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