a tool for identifying drug-targetable redox-active disulphides

Paternally-expressed gene 3 protein

Intermolecular

Cysteine 71 and cysteine 114

A redox-regulated disulphide may form between two units of Paternally-expressed gene 3 protein at cysteines 71 and 114 (34 and 77 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

33

PDB code

Structure name

crystal structure of the scan domain from human paternally expressed gene 3 protein

Structure deposition date

2013-04-09

Thiol separation (Å)

10

Half-sphere exposure sum ?

67

Minimum pK_a ?

12

% buried

88

Peptide A name

Paternally-expressed gene 3 protein

Peptide B name

Paternally-expressed gene 3 protein

Peptide A accession

Peptide B accession

Peptide A residue number

71

Peptide B residue number

114

Ligandability

Cysteine 71 of Paternally-expressed gene 3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 114 of Paternally-expressed gene 3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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