ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

Intramolecular
Cysteine 92 and cysteine 148
A redox-regulated disulphide may form within Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 between cysteines 92 and 148. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
3l0y
Structure name
crystal structure of scp1 phosphatase d98a mutant
Structure deposition date
2009-12-10
Thiol separation (Å)
8
Half-sphere exposure sum ?
84
Minimum pKa ?
12
% buried
98
Peptide accession
Q9GZU7
Residue number A
92
Residue number B
148
Peptide name
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

Ligandability

Cysteine 92 of Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 148 of Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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