a tool for identifying drug-targetable redox-active disulphides

Fibroblast growth factor 23

Intramolecular

Cysteine 95 and cysteine 113

A redox-regulated disulphide may form within Fibroblast growth factor 23 between cysteines 95 and 113.

Details

Redox score ?

79

PDB code

Structure name

crystal structure of a 1:1:1 fgf23-fgfr1c-aklotho ternary complex

Structure deposition date

2017-06-05

Thiol separation (Å)

2

Half-sphere exposure sum ?

73

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

95

Residue number B

113

Peptide name

Fibroblast growth factor 23

Ligandability

Cysteine 95 of Fibroblast growth factor 23

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 113 of Fibroblast growth factor 23

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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