a tool for identifying drug-targetable redox-active disulphides

Phospholysine phosphohistidine inorganic pyrophosphate phosphatase

Intramolecular

Cysteine 53 and cysteine 226

A redox-regulated disulphide may form within Phospholysine phosphohistidine inorganic pyrophosphate phosphatase between cysteines 53 and 226. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

38

PDB code

Structure name

crystal structure of human phospholysine phosphohistidine inorganic pyrophosphate phosphatase lhpp

Structure deposition date

2010-01-29

Thiol separation (Å)

9

Half-sphere exposure sum ?

76

Minimum pK_a ?

10

% buried

68

Peptide accession

Residue number A

53

Residue number B

226

Peptide name

Phospholysine phosphohistidine inorganic pyrophosphate phosphatase

Ligandability

Cysteine 53 of Phospholysine phosphohistidine inorganic pyrophosphate phosphatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 226 of Phospholysine phosphohistidine inorganic pyrophosphate phosphatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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