ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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DNA-dependent metalloprotease SPRTN

Intramolecular
Cysteine 169 and cysteine 205
Cysteine 173 and cysteine 205
Cysteine 169 and cysteine 173
Cysteine 79 and cysteine 88
A redox-regulated disulphide may form within DNA-dependent metalloprotease SPRTN between cysteines 169 and 205.

Details

Redox score ?
85
PDB code
6mdw
Structure name
mechanism of protease dependent dpc repair
Structure deposition date
2018-09-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
7
% buried
26
Peptide accession
Q9H040
Residue number A
169
Residue number B
205
Peptide name
DNA-dependent metalloprotease SPRTN

Ligandability

Cysteine 169 of DNA-dependent metalloprotease SPRTN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 205 of DNA-dependent metalloprotease SPRTN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA-dependent metalloprotease SPRTN between cysteines 173 and 205.

Details

Redox score ?
82
PDB code
6mdx
Structure name
mechanism of protease dependent dpc repair
Structure deposition date
2018-09-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
50
Minimum pKa ?
7
% buried
34
Peptide accession
Q9H040
Residue number A
173
Residue number B
205
Peptide name
DNA-dependent metalloprotease SPRTN

Ligandability

Cysteine 173 of DNA-dependent metalloprotease SPRTN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 205 of DNA-dependent metalloprotease SPRTN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA-dependent metalloprotease SPRTN between cysteines 169 and 173.

Details

Redox score ?
80
PDB code
6mdw
Structure name
mechanism of protease dependent dpc repair
Structure deposition date
2018-09-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
56
Minimum pKa ?
8
% buried
44
Peptide accession
Q9H040
Residue number A
169
Residue number B
173
Peptide name
DNA-dependent metalloprotease SPRTN

Ligandability

Cysteine 169 of DNA-dependent metalloprotease SPRTN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 173 of DNA-dependent metalloprotease SPRTN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within DNA-dependent metalloprotease SPRTN between cysteines 79 and 88.

Details

Redox score ?
72
PDB code
6mdx
Structure name
mechanism of protease dependent dpc repair
Structure deposition date
2018-09-05
Thiol separation (Å)
5
Half-sphere exposure sum ?
nan
Minimum pKa ?
8
% buried
85
Peptide accession
Q9H040
Residue number A
79
Residue number B
88
Peptide name
DNA-dependent metalloprotease SPRTN

Ligandability

Cysteine 79 of DNA-dependent metalloprotease SPRTN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 88 of DNA-dependent metalloprotease SPRTN

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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