a tool for identifying drug-targetable redox-active disulphides

Repressor of RNA polymerase III transcription MAF1 homolog

Intramolecular

Cysteine 159 and cysteine 163

A redox-regulated disulphide may form within Repressor of RNA polymerase III transcription MAF1 homolog between cysteines 159 and 163 (112 and 116 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

58

PDB code

Structure name

crystal structure of human maf1

Structure deposition date

2010-06-30

Thiol separation (Å)

7

Half-sphere exposure sum ?

53

Minimum pK_a ?

10

% buried

29

Peptide accession

Residue number A

159

Residue number B

163

Peptide name

Repressor of RNA polymerase III transcription MAF1 homolog

Ligandability

Cysteine 159 of Repressor of RNA polymerase III transcription MAF1 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 163 of Repressor of RNA polymerase III transcription MAF1 homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: