ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Polyadenylate-binding protein-interacting protein 1

Intramolecular
Cysteine 222 and cysteine 246
A redox-regulated disulphide may form within Polyadenylate-binding protein-interacting protein 1 between cysteines 222 and 246 (143 and 167 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
3rk6
Structure name
crystal structure of the middle domain of human paip1
Structure deposition date
2011-04-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
73
Minimum pKa ?
12
% buried
100
Peptide accession
Q9H074
Residue number A
222
Residue number B
246
Peptide name
Polyadenylate-binding protein-interacting protein 1

Ligandability

Cysteine 222 of Polyadenylate-binding protein-interacting protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 246 of Polyadenylate-binding protein-interacting protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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