ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Kinesin light chain 2

Intermolecular
Cysteine 221 and cysteine 221 L
Intramolecular
Cysteine 441 and cysteine 474 L
Cysteine 305 and cysteine 334
Cysteine 334 and cysteine 375
A redox-regulated disulphide may form between two units of Kinesin light chain 2 at cysteines 221 and 221. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
3ceq
Structure name
the tpr domain of human kinesin light chain 2 (hklc2)
Structure deposition date
2008-02-29
Thiol separation (Å)
7
Half-sphere exposure sum ?
80
Minimum pKa ?
12
% buried
92
Peptide A name
Kinesin light chain 2
Peptide B name
Kinesin light chain 2
Peptide A accession
Q9H0B6
Peptide B accession
Q9H0B6
Peptide A residue number
221
Peptide B residue number
221

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Kinesin light chain 2 between cysteines 441 and 474.

Details

Redox score ?
75
PDB code
3edt
Structure name
crystal structure of the mutated s328n hklc2 tpr domain
Structure deposition date
2008-09-03
Thiol separation (Å)
3
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H0B6
Residue number A
441
Residue number B
474
Peptide name
Kinesin light chain 2

Ligandability

Cysteine 441 of Kinesin light chain 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 474 of Kinesin light chain 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Kinesin light chain 2 between cysteines 305 and 334. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
3ceq
Structure name
the tpr domain of human kinesin light chain 2 (hklc2)
Structure deposition date
2008-02-29
Thiol separation (Å)
8
Half-sphere exposure sum ?
70
Minimum pKa ?
11
% buried
60
Peptide accession
Q9H0B6
Residue number A
305
Residue number B
334
Peptide name
Kinesin light chain 2

Ligandability

Cysteine 305 of Kinesin light chain 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 334 of Kinesin light chain 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Kinesin light chain 2 between cysteines 334 and 375. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
3edt
Structure name
crystal structure of the mutated s328n hklc2 tpr domain
Structure deposition date
2008-09-03
Thiol separation (Å)
10
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H0B6
Residue number A
334
Residue number B
375
Peptide name
Kinesin light chain 2

Ligandability

Cysteine 334 of Kinesin light chain 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 375 of Kinesin light chain 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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