a tool for identifying drug-targetable redox-active disulphides

Sharpin

Intramolecular

Cysteine 275 and cysteine 277

A redox-regulated disulphide may form within Sharpin between cysteines 275 and 277.

Details

Redox score ?

69

PDB code

Structure name

molecular mechanism for the binding between sharpin and hoip

Structure deposition date

2017-01-23

Thiol separation (Å)

5

Half-sphere exposure sum ?

69

Minimum pK_a ?

9

% buried

42

Peptide accession

Residue number A

275

Residue number B

277

Peptide name

Sharpin

Ligandability

Cysteine 275 of Sharpin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 277 of Sharpin

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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