Integrator complex subunit 2
Intermolecular
Cysteine 722 and cysteine 82 of Integrator complex subunit 7
Cysteine 722 and cysteine 42 of Integrator complex subunit 7 L
Intramolecular
Cysteine 1132 and cysteine 1186
Cysteine 946 and cysteine 998
Cysteine 995 and cysteine 998
Cysteine 995 and cysteine 999
Cysteine 393 and cysteine 434
Cysteine 998 and cysteine 999
Cysteine 434 and cysteine 500
Cysteine 946 and cysteine 995
More...Cysteine 1132 and cysteine 1188
Cysteine 988 and cysteine 995
7cun B 722 G 82
A redox-regulated disulphide may form between cysteine 722 of Integrator complex subunit 2 and cysteine 82 of Integrator complex subunit 7. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
7cun
Structure name
the structure of human integrator-pp2a complex
Structure deposition date
2020-08-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
77
Minimum pKa ?
8
% buried
100
Peptide A name
Integrator complex subunit 2
Peptide B name
Integrator complex subunit 7
Peptide A accession
Q9H0H0
Peptide B accession
Q9NVH2
Peptide A residue number
722
Peptide B residue number
82
Ligandability
Cysteine 722 of Integrator complex subunit 2
Cysteine 82 of Integrator complex subunit 7
7cun B 722 G 42
A redox-regulated disulphide may form between cysteine 722 of Integrator complex subunit 2 and cysteine 42 of Integrator complex subunit 7. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
7cun
Structure name
the structure of human integrator-pp2a complex
Structure deposition date
2020-08-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
79
Minimum pKa ?
12
% buried
92
Peptide A name
Integrator complex subunit 2
Peptide B name
Integrator complex subunit 7
Peptide A accession
Q9H0H0
Peptide B accession
Q9NVH2
Peptide A residue number
722
Peptide B residue number
42
Ligandability
Cysteine 722 of Integrator complex subunit 2
Cysteine 42 of Integrator complex subunit 7
7cun B 1132 B 1186
A redox-regulated disulphide may form within Integrator complex subunit 2 between cysteines 1132 and 1186.
Details
Redox score ?
63
PDB code
7cun
Structure name
the structure of human integrator-pp2a complex
Structure deposition date
2020-08-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
82
Minimum pKa ?
9
% buried
100
Peptide accession
Q9H0H0
Residue number A
1132
Residue number B
1186
Peptide name
Integrator complex subunit 2
Ligandability
Cysteine 1132 of Integrator complex subunit 2
Cysteine 1186 of Integrator complex subunit 2
7cun B 946 B 998
A redox-regulated disulphide may form within Integrator complex subunit 2 between cysteines 946 and 998. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
7cun
Structure name
the structure of human integrator-pp2a complex
Structure deposition date
2020-08-23
Thiol separation (Å)
6
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
100
Peptide accession
Q9H0H0
Residue number A
946
Residue number B
998
Peptide name
Integrator complex subunit 2
Ligandability
Cysteine 946 of Integrator complex subunit 2
Cysteine 998 of Integrator complex subunit 2
7cun B 995 B 998
A redox-regulated disulphide may form within Integrator complex subunit 2 between cysteines 995 and 998. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
7cun
Structure name
the structure of human integrator-pp2a complex
Structure deposition date
2020-08-23
Thiol separation (Å)
6
Half-sphere exposure sum ?
84
Minimum pKa ?
10
% buried
99
Peptide accession
Q9H0H0
Residue number A
995
Residue number B
998
Peptide name
Integrator complex subunit 2
Ligandability
Cysteine 995 of Integrator complex subunit 2
Cysteine 998 of Integrator complex subunit 2
7cun B 995 B 999
A redox-regulated disulphide may form within Integrator complex subunit 2 between cysteines 995 and 999. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
7cun
Structure name
the structure of human integrator-pp2a complex
Structure deposition date
2020-08-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
85
Minimum pKa ?
10
% buried
99
Peptide accession
Q9H0H0
Residue number A
995
Residue number B
999
Peptide name
Integrator complex subunit 2
Ligandability
Cysteine 995 of Integrator complex subunit 2
Cysteine 999 of Integrator complex subunit 2
7cun B 393 B 434
A redox-regulated disulphide may form within Integrator complex subunit 2 between cysteines 393 and 434. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
7cun
Structure name
the structure of human integrator-pp2a complex
Structure deposition date
2020-08-23
Thiol separation (Å)
8
Half-sphere exposure sum ?
71
Minimum pKa ?
11
% buried
96
Peptide accession
Q9H0H0
Residue number A
393
Residue number B
434
Peptide name
Integrator complex subunit 2
Ligandability
Cysteine 393 of Integrator complex subunit 2
Cysteine 434 of Integrator complex subunit 2
7cun B 998 B 999
A redox-regulated disulphide may form within Integrator complex subunit 2 between cysteines 998 and 999. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
7cun
Structure name
the structure of human integrator-pp2a complex
Structure deposition date
2020-08-23
Thiol separation (Å)
7
Half-sphere exposure sum ?
83
Minimum pKa ?
12
% buried
100
Peptide accession
Q9H0H0
Residue number A
998
Residue number B
999
Peptide name
Integrator complex subunit 2
Ligandability
Cysteine 998 of Integrator complex subunit 2
Cysteine 999 of Integrator complex subunit 2
7cun B 434 B 500
A redox-regulated disulphide may form within Integrator complex subunit 2 between cysteines 434 and 500. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
7cun
Structure name
the structure of human integrator-pp2a complex
Structure deposition date
2020-08-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
63
Peptide accession
Q9H0H0
Residue number A
434
Residue number B
500
Peptide name
Integrator complex subunit 2
Ligandability
Cysteine 434 of Integrator complex subunit 2
Cysteine 500 of Integrator complex subunit 2
7cun B 946 B 995
A redox-regulated disulphide may form within Integrator complex subunit 2 between cysteines 946 and 995. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
7cun
Structure name
the structure of human integrator-pp2a complex
Structure deposition date
2020-08-23
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
10
% buried
99
Peptide accession
Q9H0H0
Residue number A
946
Residue number B
995
Peptide name
Integrator complex subunit 2
Ligandability
Cysteine 946 of Integrator complex subunit 2
Cysteine 995 of Integrator complex subunit 2
7cun B 1132 B 1188
A redox-regulated disulphide may form within Integrator complex subunit 2 between cysteines 1132 and 1188. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
7cun
Structure name
the structure of human integrator-pp2a complex
Structure deposition date
2020-08-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
71
Minimum pKa ?
9
% buried
76
Peptide accession
Q9H0H0
Residue number A
1132
Residue number B
1188
Peptide name
Integrator complex subunit 2
Ligandability
Cysteine 1132 of Integrator complex subunit 2
Cysteine 1188 of Integrator complex subunit 2
7cun B 988 B 995
A redox-regulated disulphide may form within Integrator complex subunit 2 between cysteines 988 and 995. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
7cun
Structure name
the structure of human integrator-pp2a complex
Structure deposition date
2020-08-23
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
10
% buried
76
Peptide accession
Q9H0H0
Residue number A
988
Residue number B
995
Peptide name
Integrator complex subunit 2
Ligandability
Cysteine 988 of Integrator complex subunit 2
Cysteine 995 of Integrator complex subunit 2
If this tool was useful for finding a disulphide, please cite: