ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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NEDD4-like E3 ubiquitin-protein ligase WWP1

Intramolecular
Cysteine 802 and cysteine 854
Cysteine 640 and cysteine 890 L
Cysteine 640 and cysteine 854
Cysteine 640 and cysteine 802
A redox-regulated disulphide may form within NEDD4-like E3 ubiquitin-protein ligase WWP1 between cysteines 802 and 854.

Details

Redox score ?
73
PDB code
6j1y
Structure name
semi-open conformation e3 ligase
Structure deposition date
2018-12-30
Thiol separation (Å)
3
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H0M0
Residue number A
802
Residue number B
854
Peptide name
NEDD4-like E3 ubiquitin-protein ligase WWP1

Ligandability

Cysteine 802 of NEDD4-like E3 ubiquitin-protein ligase WWP1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 854 of NEDD4-like E3 ubiquitin-protein ligase WWP1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NEDD4-like E3 ubiquitin-protein ligase WWP1 between cysteines 640 and 890. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
6j1x
Structure name
wwp1 close conformation
Structure deposition date
2018-12-30
Thiol separation (Å)
7
Half-sphere exposure sum ?
76
Minimum pKa ?
10
% buried
76
Peptide accession
Q9H0M0
Residue number A
640
Residue number B
890
Peptide name
NEDD4-like E3 ubiquitin-protein ligase WWP1

Ligandability

Cysteine 640 of NEDD4-like E3 ubiquitin-protein ligase WWP1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 890 of NEDD4-like E3 ubiquitin-protein ligase WWP1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NEDD4-like E3 ubiquitin-protein ligase WWP1 between cysteines 640 and 854. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
1nd7
Structure name
conformational flexibility underlies ubiquitin ligation mediated by the wwp1 hect domain e3 ligase
Structure deposition date
2002-12-08
Thiol separation (Å)
9
Half-sphere exposure sum ?
74
Minimum pKa ?
11
% buried
92
Peptide accession
Q9H0M0
Residue number A
640
Residue number B
854
Peptide name
NEDD4-like E3 ubiquitin-protein ligase WWP1

Ligandability

Cysteine 640 of NEDD4-like E3 ubiquitin-protein ligase WWP1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 854 of NEDD4-like E3 ubiquitin-protein ligase WWP1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NEDD4-like E3 ubiquitin-protein ligase WWP1 between cysteines 640 and 802. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
5hpt
Structure name
system-wide modulation of hect e3 ligases with selective ubiquitin variant probes: wwp1, ubv p2
Structure deposition date
2016-01-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
64
Minimum pKa ?
11
% buried
100
Peptide accession
Q9H0M0
Residue number A
640
Residue number B
802
Peptide name
NEDD4-like E3 ubiquitin-protein ligase WWP1

Ligandability

Cysteine 640 of NEDD4-like E3 ubiquitin-protein ligase WWP1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 802 of NEDD4-like E3 ubiquitin-protein ligase WWP1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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