a tool for identifying drug-targetable redox-active disulphides

Cytosolic 5'-nucleotidase 3A

Intramolecular

Cysteine 108 and cysteine 115

A redox-regulated disulphide may form within Cytosolic 5'-nucleotidase 3A between cysteines 108 and 115 (74 and 81 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

48

PDB code

Structure name

ensemble refinement of the protein crystal structure of a cytosolic 5'-nucleotidase iii from mus musculus mm

Structure deposition date

2007-05-31

Thiol separation (Å)

9

Half-sphere exposure sum ?

57

Minimum pK_a ?

10

% buried

37

Peptide accession

Residue number A

108

Residue number B

115

Peptide name

Cytosolic 5'-nucleotidase 3A

Ligandability

Cysteine 108 of Cytosolic 5'-nucleotidase 3A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 115 of Cytosolic 5'-nucleotidase 3A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: