Nonsense-mediated mRNA decay factor SMG9

Intermolecular

Cysteine 492 of Serine/threonine-protein kinase SMG1 and cysteine 380 L

A redox-regulated disulphide may form between cysteine 492 of Serine/threonine-protein kinase SMG1 and cysteine 380 of Nonsense-mediated mRNA decay factor SMG9.

Details

Redox score ?

PDB code

6l54

Structure name

structure of smg189

Structure deposition date

2019-10-22

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

100

Peptide A name

Serine/threonine-protein kinase SMG1

Peptide B name

Nonsense-mediated mRNA decay factor SMG9

Peptide A accession

Q96Q15

Peptide B accession

Q9H0W8

Peptide A residue number

492

Peptide B residue number

380

Ligandability

Cysteine 492 of Serine/threonine-protein kinase SMG1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 380 of Nonsense-mediated mRNA decay factor SMG9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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