a tool for identifying drug-targetable redox-active disulphides

Deoxynucleotidyltransferase terminal-interacting protein 1

Intramolecular

Cysteine 118 and cysteine 121

A redox-regulated disulphide may form within Deoxynucleotidyltransferase terminal-interacting protein 1 between cysteines 118 and 121. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

48

PDB code

Structure name

structure of dnttip1 dimerisation domain

Structure deposition date

2014-11-11

Thiol separation (Å)

6

Half-sphere exposure sum ?

81

Minimum pK_a ?

12

% buried

82

Peptide accession

Residue number A

118

Residue number B

121

Peptide name

Deoxynucleotidyltransferase terminal-interacting protein 1

Ligandability

Cysteine 118 of Deoxynucleotidyltransferase terminal-interacting protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 121 of Deoxynucleotidyltransferase terminal-interacting protein 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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