Probable E3 ubiquitin-protein ligase IRF2BPL
Intramolecular
Cysteine 715 and cysteine 718
Cysteine 730 and cysteine 764
Cysteine 715 and cysteine 742
Cysteine 730 and cysteine 758
Cysteine 715 and cysteine 739
Cysteine 718 and cysteine 742
Cysteine 718 and cysteine 739
Cysteine 758 and cysteine 764
Cysteine 739 and cysteine 742
Cysteine 714 and cysteine 715
Cysteine 714 and cysteine 718
2cs3 A 18 A 21
A redox-regulated disulphide may form within Probable E3 ubiquitin-protein ligase IRF2BPL between cysteines 715 and 718 (18 and 21 respectively in this structure).
Details
Redox score ?
87
PDB code
2cs3
Structure name
solution structure of the zf-c3hc4 domain of human kiaa1865
Structure deposition date
2005-05-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
5
% buried
14
Peptide accession
Q9H1B7
Residue number A
715
Residue number B
718
Peptide name
Probable E3 ubiquitin-protein ligase IRF2BPL
Ligandability
Cysteine 715 of Probable E3 ubiquitin-protein ligase IRF2BPL
Cysteine 718 of Probable E3 ubiquitin-protein ligase IRF2BPL
2cs3 A 33 A 67
A redox-regulated disulphide may form within Probable E3 ubiquitin-protein ligase IRF2BPL between cysteines 730 and 764 (33 and 67 respectively in this structure).
Details
Redox score ?
87
PDB code
2cs3
Structure name
solution structure of the zf-c3hc4 domain of human kiaa1865
Structure deposition date
2005-05-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
57
Minimum pKa ?
5
% buried
13
Peptide accession
Q9H1B7
Residue number A
730
Residue number B
764
Peptide name
Probable E3 ubiquitin-protein ligase IRF2BPL
Ligandability
Cysteine 730 of Probable E3 ubiquitin-protein ligase IRF2BPL
Cysteine 764 of Probable E3 ubiquitin-protein ligase IRF2BPL
2cs3 A 18 A 45
A redox-regulated disulphide may form within Probable E3 ubiquitin-protein ligase IRF2BPL between cysteines 715 and 742 (18 and 45 respectively in this structure).
Details
Redox score ?
85
PDB code
2cs3
Structure name
solution structure of the zf-c3hc4 domain of human kiaa1865
Structure deposition date
2005-05-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
5
% buried
26
Peptide accession
Q9H1B7
Residue number A
715
Residue number B
742
Peptide name
Probable E3 ubiquitin-protein ligase IRF2BPL
Ligandability
Cysteine 715 of Probable E3 ubiquitin-protein ligase IRF2BPL
Cysteine 742 of Probable E3 ubiquitin-protein ligase IRF2BPL
2cs3 A 33 A 61
A redox-regulated disulphide may form within Probable E3 ubiquitin-protein ligase IRF2BPL between cysteines 730 and 758 (33 and 61 respectively in this structure).
Details
Redox score ?
84
PDB code
2cs3
Structure name
solution structure of the zf-c3hc4 domain of human kiaa1865
Structure deposition date
2005-05-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
65
Minimum pKa ?
5
% buried
28
Peptide accession
Q9H1B7
Residue number A
730
Residue number B
758
Peptide name
Probable E3 ubiquitin-protein ligase IRF2BPL
Ligandability
Cysteine 730 of Probable E3 ubiquitin-protein ligase IRF2BPL
Cysteine 758 of Probable E3 ubiquitin-protein ligase IRF2BPL
2cs3 A 18 A 42
A redox-regulated disulphide may form within Probable E3 ubiquitin-protein ligase IRF2BPL between cysteines 715 and 739 (18 and 42 respectively in this structure).
Details
Redox score ?
84
PDB code
2cs3
Structure name
solution structure of the zf-c3hc4 domain of human kiaa1865
Structure deposition date
2005-05-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
64
Minimum pKa ?
5
% buried
26
Peptide accession
Q9H1B7
Residue number A
715
Residue number B
739
Peptide name
Probable E3 ubiquitin-protein ligase IRF2BPL
Ligandability
Cysteine 715 of Probable E3 ubiquitin-protein ligase IRF2BPL
Cysteine 739 of Probable E3 ubiquitin-protein ligase IRF2BPL
2cs3 A 21 A 45
A redox-regulated disulphide may form within Probable E3 ubiquitin-protein ligase IRF2BPL between cysteines 718 and 742 (21 and 45 respectively in this structure).
Details
Redox score ?
80
PDB code
2cs3
Structure name
solution structure of the zf-c3hc4 domain of human kiaa1865
Structure deposition date
2005-05-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
48
Minimum pKa ?
9
% buried
18
Peptide accession
Q9H1B7
Residue number A
718
Residue number B
742
Peptide name
Probable E3 ubiquitin-protein ligase IRF2BPL
Ligandability
Cysteine 718 of Probable E3 ubiquitin-protein ligase IRF2BPL
Cysteine 742 of Probable E3 ubiquitin-protein ligase IRF2BPL
2cs3 A 21 A 42
A redox-regulated disulphide may form within Probable E3 ubiquitin-protein ligase IRF2BPL between cysteines 718 and 739 (21 and 42 respectively in this structure).
Details
Redox score ?
78
PDB code
2cs3
Structure name
solution structure of the zf-c3hc4 domain of human kiaa1865
Structure deposition date
2005-05-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
52
Minimum pKa ?
9
% buried
18
Peptide accession
Q9H1B7
Residue number A
718
Residue number B
739
Peptide name
Probable E3 ubiquitin-protein ligase IRF2BPL
Ligandability
Cysteine 718 of Probable E3 ubiquitin-protein ligase IRF2BPL
Cysteine 739 of Probable E3 ubiquitin-protein ligase IRF2BPL
2cs3 A 61 A 67
A redox-regulated disulphide may form within Probable E3 ubiquitin-protein ligase IRF2BPL between cysteines 758 and 764 (61 and 67 respectively in this structure).
Details
Redox score ?
76
PDB code
2cs3
Structure name
solution structure of the zf-c3hc4 domain of human kiaa1865
Structure deposition date
2005-05-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
20
Peptide accession
Q9H1B7
Residue number A
758
Residue number B
764
Peptide name
Probable E3 ubiquitin-protein ligase IRF2BPL
Ligandability
Cysteine 758 of Probable E3 ubiquitin-protein ligase IRF2BPL
Cysteine 764 of Probable E3 ubiquitin-protein ligase IRF2BPL
2cs3 A 42 A 45
A redox-regulated disulphide may form within Probable E3 ubiquitin-protein ligase IRF2BPL between cysteines 739 and 742 (42 and 45 respectively in this structure).
Details
Redox score ?
72
PDB code
2cs3
Structure name
solution structure of the zf-c3hc4 domain of human kiaa1865
Structure deposition date
2005-05-20
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
11
% buried
30
Peptide accession
Q9H1B7
Residue number A
739
Residue number B
742
Peptide name
Probable E3 ubiquitin-protein ligase IRF2BPL
Ligandability
Cysteine 739 of Probable E3 ubiquitin-protein ligase IRF2BPL
Cysteine 742 of Probable E3 ubiquitin-protein ligase IRF2BPL
2cs3 A 17 A 18
A redox-regulated disulphide may form within Probable E3 ubiquitin-protein ligase IRF2BPL between cysteines 714 and 715 (17 and 18 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
2cs3
Structure name
solution structure of the zf-c3hc4 domain of human kiaa1865
Structure deposition date
2005-05-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
57
Minimum pKa ?
5
% buried
11
Peptide accession
Q9H1B7
Residue number A
714
Residue number B
715
Peptide name
Probable E3 ubiquitin-protein ligase IRF2BPL
Ligandability
Cysteine 714 of Probable E3 ubiquitin-protein ligase IRF2BPL
Cysteine 715 of Probable E3 ubiquitin-protein ligase IRF2BPL
2cs3 A 17 A 21
A redox-regulated disulphide may form within Probable E3 ubiquitin-protein ligase IRF2BPL between cysteines 714 and 718 (17 and 21 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
2cs3
Structure name
solution structure of the zf-c3hc4 domain of human kiaa1865
Structure deposition date
2005-05-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
46
Minimum pKa ?
9
% buried
2
Peptide accession
Q9H1B7
Residue number A
714
Residue number B
718
Peptide name
Probable E3 ubiquitin-protein ligase IRF2BPL
Ligandability
Cysteine 714 of Probable E3 ubiquitin-protein ligase IRF2BPL
Cysteine 718 of Probable E3 ubiquitin-protein ligase IRF2BPL
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