ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Transient receptor potential cation channel subfamily V member 6

Intramolecular
Cysteine 382 and cysteine 386
Cysteine 386 and cysteine 387
Cysteine 382 and cysteine 387
A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily V member 6 between cysteines 382 and 386 (342 and 346 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
7k4c
Structure name
cryo-em structure of human trpv6 in complex with (4- phenylcyclohexyl)piperazine inhibitor br-cis-22a
Structure deposition date
2020-09-15
Thiol separation (Å)
7
Half-sphere exposure sum ?
59
Minimum pKa ?
10
% buried
42
Peptide accession
Q9H1D0
Residue number A
382
Residue number B
386
Peptide name
Transient receptor potential cation channel subfamily V member 6

Ligandability

Cysteine 382 of Transient receptor potential cation channel subfamily V member 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 386 of Transient receptor potential cation channel subfamily V member 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily V member 6 between cysteines 386 and 387 (346 and 347 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
6e2f
Structure name
cryo-em structure of human trpv6 in complex with calmodulin
Structure deposition date
2018-07-11
Thiol separation (Å)
7
Half-sphere exposure sum ?
58
Minimum pKa ?
12
% buried
84
Peptide accession
Q9H1D0
Residue number A
386
Residue number B
387
Peptide name
Transient receptor potential cation channel subfamily V member 6

Ligandability

Cysteine 386 of Transient receptor potential cation channel subfamily V member 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 387 of Transient receptor potential cation channel subfamily V member 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Transient receptor potential cation channel subfamily V member 6 between cysteines 382 and 387 (342 and 347 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
7s88
Structure name
open apo-state cryo-em structure of human trpv6 in glyco-diosgenin detergent
Structure deposition date
2021-09-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
65
Minimum pKa ?
10
% buried
87
Peptide accession
Q9H1D0
Residue number A
382
Residue number B
387
Peptide name
Transient receptor potential cation channel subfamily V member 6

Ligandability

Cysteine 382 of Transient receptor potential cation channel subfamily V member 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 387 of Transient receptor potential cation channel subfamily V member 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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