DNA-directed RNA polymerase III subunit RPC6
Intermolecular
Cysteine 439 of DNA-directed RNA polymerase III subunit RPC3 and cysteine 287
Intramolecular
Cysteine 296 and cysteine 307
Cysteine 290 and cysteine 307
Cysteine 290 and cysteine 296
Cysteine 287 and cysteine 296
Cysteine 287 and cysteine 307
Cysteine 287 and cysteine 290
7fji O 439 P 287
A redox-regulated disulphide may form between cysteine 439 of DNA-directed RNA polymerase III subunit RPC3 and cysteine 287 of DNA-directed RNA polymerase III subunit RPC6. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
7fji
Structure name
human pol iii elongation complex
Structure deposition date
2021-08-04
Thiol separation (Å)
10
Half-sphere exposure sum ?
84
Minimum pKa ?
6
% buried
100
Peptide A name
DNA-directed RNA polymerase III subunit RPC3
Peptide B name
DNA-directed RNA polymerase III subunit RPC6
Peptide A accession
Q9BUI4
Peptide B accession
Q9H1D9
Peptide A residue number
439
Peptide B residue number
287
Ligandability
Cysteine 439 of DNA-directed RNA polymerase III subunit RPC3
Cysteine 287 of DNA-directed RNA polymerase III subunit RPC6
7ae3 P 296 P 307
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC6 between cysteines 296 and 307. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
7ae3
Structure name
cryo-em structure of human rna polymerase iii elongation complex 3
Structure deposition date
2020-09-17
Thiol separation (Å)
7
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
68
Peptide accession
Q9H1D9
Residue number A
296
Residue number B
307
Peptide name
DNA-directed RNA polymerase III subunit RPC6
Ligandability
Cysteine 296 of DNA-directed RNA polymerase III subunit RPC6
Cysteine 307 of DNA-directed RNA polymerase III subunit RPC6
7fjj P 290 P 307
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC6 between cysteines 290 and 307. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
7fjj
Structure name
human pol iii pre-termination complex
Structure deposition date
2021-08-04
Thiol separation (Å)
7
Half-sphere exposure sum ?
64
Minimum pKa ?
11
% buried
80
Peptide accession
Q9H1D9
Residue number A
290
Residue number B
307
Peptide name
DNA-directed RNA polymerase III subunit RPC6
Ligandability
Cysteine 290 of DNA-directed RNA polymerase III subunit RPC6
Cysteine 307 of DNA-directed RNA polymerase III subunit RPC6
7a6h P 290 P 296
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC6 between cysteines 290 and 296. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
7a6h
Structure name
cryo-em structure of human apo rna polymerase iii
Structure deposition date
2020-08-25
Thiol separation (Å)
7
Half-sphere exposure sum ?
68
Minimum pKa ?
11
% buried
83
Peptide accession
Q9H1D9
Residue number A
290
Residue number B
296
Peptide name
DNA-directed RNA polymerase III subunit RPC6
Ligandability
Cysteine 290 of DNA-directed RNA polymerase III subunit RPC6
Cysteine 296 of DNA-directed RNA polymerase III subunit RPC6
7a6h P 287 P 296
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC6 between cysteines 287 and 296. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
7a6h
Structure name
cryo-em structure of human apo rna polymerase iii
Structure deposition date
2020-08-25
Thiol separation (Å)
7
Half-sphere exposure sum ?
71
Minimum pKa ?
11
% buried
88
Peptide accession
Q9H1D9
Residue number A
287
Residue number B
296
Peptide name
DNA-directed RNA polymerase III subunit RPC6
Ligandability
Cysteine 287 of DNA-directed RNA polymerase III subunit RPC6
Cysteine 296 of DNA-directed RNA polymerase III subunit RPC6
7ae3 P 287 P 307
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC6 between cysteines 287 and 307. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
7ae3
Structure name
cryo-em structure of human rna polymerase iii elongation complex 3
Structure deposition date
2020-09-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
74
Minimum pKa ?
10
% buried
83
Peptide accession
Q9H1D9
Residue number A
287
Residue number B
307
Peptide name
DNA-directed RNA polymerase III subunit RPC6
Ligandability
Cysteine 287 of DNA-directed RNA polymerase III subunit RPC6
Cysteine 307 of DNA-directed RNA polymerase III subunit RPC6
7aea P 287 P 290
A redox-regulated disulphide may form within DNA-directed RNA polymerase III subunit RPC6 between cysteines 287 and 290. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
7aea
Structure name
cryo-em structure of human rna polymerase iii elongation complex 2
Structure deposition date
2020-09-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
88
Peptide accession
Q9H1D9
Residue number A
287
Residue number B
290
Peptide name
DNA-directed RNA polymerase III subunit RPC6
Ligandability
Cysteine 287 of DNA-directed RNA polymerase III subunit RPC6
Cysteine 290 of DNA-directed RNA polymerase III subunit RPC6
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