ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Talin rod domain-containing protein 1

Intermolecular
Cysteine 220 and cysteine 220
A redox-regulated disulphide may form between two units of Talin rod domain-containing protein 1 at cysteines 220 and 220. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
6xz4
Structure name
crystal structure of tlnrd1
Structure deposition date
2020-02-01
Thiol separation (Å)
6
Half-sphere exposure sum ?
87
Minimum pKa ?
11
% buried
96
Peptide A name
Talin rod domain-containing protein 1
Peptide B name
Talin rod domain-containing protein 1
Peptide A accession
Q9H1K6
Peptide B accession
Q9H1K6
Peptide A residue number
220
Peptide B residue number
220

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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