a tool for identifying drug-targetable redox-active disulphides

Dual specificity protein phosphatase 15

Intermolecular

Cysteine 73 and cysteine 73

A redox-regulated disulphide may form between two units of Dual specificity protein phosphatase 15 at cysteines 73 and 73 (76 and 76 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

39

PDB code

Structure name

crystal structure of dusp15

Structure deposition date

2005-02-28

Thiol separation (Å)

8

Half-sphere exposure sum ?

67

Minimum pK_a ?

12

% buried

100

Peptide A name

Dual specificity protein phosphatase 15

Peptide B name

Dual specificity protein phosphatase 15

Peptide A accession

Peptide B accession

Peptide A residue number

73

Peptide B residue number

73

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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