ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Mediator of RNA polymerase II transcription subunit 28

Intermolecular
Cysteine 649 of Mediator of RNA polymerase II transcription subunit 17 and cysteine 93 L
Intramolecular
Cysteine 55 and cysteine 80
A redox-regulated disulphide may form between cysteine 649 of Mediator of RNA polymerase II transcription subunit 17 and cysteine 93 of Mediator of RNA polymerase II transcription subunit 28. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
7emf
Structure name
human mediator (deletion of med1-idr) in a tail-extended conformation
Structure deposition date
2021-04-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
66
Peptide A name
Mediator of RNA polymerase II transcription subunit 17
Peptide B name
Mediator of RNA polymerase II transcription subunit 28
Peptide A accession
Q9NVC6
Peptide B accession
Q9H204
Peptide A residue number
649
Peptide B residue number
93

Ligandability

Cysteine 649 of Mediator of RNA polymerase II transcription subunit 17

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 93 of Mediator of RNA polymerase II transcription subunit 28

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Mediator of RNA polymerase II transcription subunit 28 between cysteines 55 and 80.

Details

Redox score ?
81
PDB code
6w1s
Structure name
atomic model of the mammalian mediator complex
Structure deposition date
2020-03-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q920D3
Residue number A
55
Residue number B
80
Peptide name
Mediator of RNA polymerase II transcription subunit 28

Ligandability

Cysteine 55 of Mediator of RNA polymerase II transcription subunit 28

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 80 of Mediator of RNA polymerase II transcription subunit 28

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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