a tool for identifying drug-targetable redox-active disulphides

DNA replication factor Cdt1

Intramolecular

Cysteine 491 and cysteine 498 L

A redox-regulated disulphide may form within DNA replication factor Cdt1 between cysteines 491 and 498 (72 and 79 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

49

PDB code

Structure name

structure of the cdt1 c-terminal domain

Structure deposition date

2009-07-06

Thiol separation (Å)

9

Half-sphere exposure sum ?

42

Minimum pK_a ?

9

% buried

1

Peptide accession

Residue number A

491

Residue number B

498

Peptide name

DNA replication factor Cdt1

Ligandability

Cysteine 491 of DNA replication factor Cdt1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 498 of DNA replication factor Cdt1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

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