ATP-binding cassette sub-family G member 5
Intermolecular
Cysteine 291 and cysteine 311 of ATP-binding cassette sub-family G member 8
Cysteine 225 and cysteine 109 of ATP-binding cassette sub-family G member 8
Intramolecular
Cysteine 587 and cysteine 600
Cysteine 287 and cysteine 335
Cysteine 274 and cysteine 335
Cysteine 83 and cysteine 274
5do7 A 291 B 311
A redox-regulated disulphide may form between cysteine 291 of ATP-binding cassette sub-family G member 5 and cysteine 311 of ATP-binding cassette sub-family G member 8. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
5do7
Structure name
crystal structure of the human sterol transporter abcg5/abcg8
Structure deposition date
2015-09-10
Thiol separation (Å)
7
Half-sphere exposure sum ?
50
Minimum pKa ?
10
% buried
40
Peptide A name
ATP-binding cassette sub-family G member 5
Peptide B name
ATP-binding cassette sub-family G member 8
Peptide A accession
Q9H222
Peptide B accession
Q9H221
Peptide A residue number
291
Peptide B residue number
311
Ligandability
Cysteine 291 of ATP-binding cassette sub-family G member 5
Cysteine 311 of ATP-binding cassette sub-family G member 8
5do7 A 225 B 109
A redox-regulated disulphide may form between cysteine 225 of ATP-binding cassette sub-family G member 5 and cysteine 109 of ATP-binding cassette sub-family G member 8. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
5do7
Structure name
crystal structure of the human sterol transporter abcg5/abcg8
Structure deposition date
2015-09-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
64
Minimum pKa ?
8
% buried
60
Peptide A name
ATP-binding cassette sub-family G member 5
Peptide B name
ATP-binding cassette sub-family G member 8
Peptide A accession
Q9H222
Peptide B accession
Q9H221
Peptide A residue number
225
Peptide B residue number
109
Ligandability
Cysteine 225 of ATP-binding cassette sub-family G member 5
Cysteine 109 of ATP-binding cassette sub-family G member 8
7r8b A 587 A 600
A redox-regulated disulphide may form within ATP-binding cassette sub-family G member 5 between cysteines 587 and 600.
Details
Redox score ?
90
PDB code
7r8b
Structure name
the structure of human abcg5/abcg8 supplemented with cholesterol
Structure deposition date
2021-06-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H222
Residue number A
587
Residue number B
600
Peptide name
ATP-binding cassette sub-family G member 5
Ligandability
Cysteine 587 of ATP-binding cassette sub-family G member 5
Cysteine 600 of ATP-binding cassette sub-family G member 5
5do7 A 287 A 335
A redox-regulated disulphide may form within ATP-binding cassette sub-family G member 5 between cysteines 287 and 335. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
5do7
Structure name
crystal structure of the human sterol transporter abcg5/abcg8
Structure deposition date
2015-09-10
Thiol separation (Å)
9
Half-sphere exposure sum ?
57
Minimum pKa ?
11
% buried
52
Peptide accession
Q9H222
Residue number A
287
Residue number B
335
Peptide name
ATP-binding cassette sub-family G member 5
Ligandability
Cysteine 287 of ATP-binding cassette sub-family G member 5
Cysteine 335 of ATP-binding cassette sub-family G member 5
5do7 C 274 C 335
A redox-regulated disulphide may form within ATP-binding cassette sub-family G member 5 between cysteines 274 and 335. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
5do7
Structure name
crystal structure of the human sterol transporter abcg5/abcg8
Structure deposition date
2015-09-10
Thiol separation (Å)
8
Half-sphere exposure sum ?
70
Minimum pKa ?
10
% buried
78
Peptide accession
Q9H222
Residue number A
274
Residue number B
335
Peptide name
ATP-binding cassette sub-family G member 5
Ligandability
Cysteine 274 of ATP-binding cassette sub-family G member 5
Cysteine 335 of ATP-binding cassette sub-family G member 5
7r89 A 83 A 274
A redox-regulated disulphide may form within ATP-binding cassette sub-family G member 5 between cysteines 83 and 274. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
31
PDB code
7r89
Structure name
the structure of human abcg5/abcg8 purified from yeast
Structure deposition date
2021-06-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
88
Minimum pKa ?
11
% buried
100
Peptide accession
Q9H222
Residue number A
83
Residue number B
274
Peptide name
ATP-binding cassette sub-family G member 5
Ligandability
Cysteine 83 of ATP-binding cassette sub-family G member 5
Cysteine 274 of ATP-binding cassette sub-family G member 5
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