ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Sphingosine 1-phosphate receptor 5

Intramolecular
Cysteine 277 and cysteine 282
Cysteine 43 and cysteine 47
A redox-regulated disulphide may form within Sphingosine 1-phosphate receptor 5 between cysteines 277 and 282.

Details

Redox score ?
88
PDB code
7ew1
Structure name
cryo-em structure of siponimod -bound sphingosine-1-phosphate receptor 5 in complex with gi protein
Structure deposition date
2021-05-24
Thiol separation (Å)
2
Half-sphere exposure sum ?
38
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9H228
Residue number A
277
Residue number B
282
Peptide name
Sphingosine 1-phosphate receptor 5

Ligandability

Cysteine 277 of Sphingosine 1-phosphate receptor 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 282 of Sphingosine 1-phosphate receptor 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Sphingosine 1-phosphate receptor 5 between cysteines 43 and 47. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
7ew1
Structure name
cryo-em structure of siponimod -bound sphingosine-1-phosphate receptor 5 in complex with gi protein
Structure deposition date
2021-05-24
Thiol separation (Å)
7
Half-sphere exposure sum ?
66
Minimum pKa ?
10
% buried
28
Peptide accession
Q9H228
Residue number A
43
Residue number B
47
Peptide name
Sphingosine 1-phosphate receptor 5

Ligandability

Cysteine 43 of Sphingosine 1-phosphate receptor 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 47 of Sphingosine 1-phosphate receptor 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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